Inflammatory mechanisms in asthma

著者

書誌事項

Inflammatory mechanisms in asthma

edited by Stephen T. Holgate, William W. Busse

（Lung biology in health and disease, v. 117）

Dekker, c1998

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis and more! Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

目次

The Pathology of Fatal Asthma, Alan L. James and Neil Carroll Bronchoscopy, Anthony J. Frew and Ratko DjukanovicM Bronchoalveolar Lavage in Studies of Asthma, Mark C. Liu and William J. Calhoun Evidence from Induced Sputum, Peter G. Gibson and Frederick E. Hargreave Mast Cell Proteases in Asthma, Andrew F. Walls Mast Cell Cytokines in Allergic Inflammation, John Joseph Costa, Stephen J. Galli, and Martin K. Church Airway Responses to Antigen in Asthmatic and Nonasthmatic Subjects, Stephen P. Peters, Joseph R. Shaver, James G. Zangrilli, and James E. Fish The Role of the Basophil in the Inflammatory Mechanisms of Asthma, L. H. Thomas and J. A. Warner Eosinophils: Granule Proteins, Maria-Cristina Seminario, Cheryl R. Adolphson, and Gerald J. Gleich Eosinophil Activation in Asthma, Shinji Motojima, Takeshi Fukuda, and Sohei Makino Eosinophil Autacoids, Anthony P. Sampson Eosinophil Cytokines, Redwan Moqbel and Paige Lacy Eosinophils in Asthma, Aparna Kumar and William W. Busse Interactions Between Eosinophils and the Airway Epithelium, Clive Robinson and Julia E. Carver Neutrophils and Asthma, L. Fabbri, Piera Boschetto, G. Caramori, and P. Maestrelli Allergen Recognition Sites in Immunoglobulin E from Patients with Asthma, Rachel E. Snow, Caroline J. Chapman, and Freda K. Stevenson T Cells in Asthma, Chris J. Corrigan Macrophages and Macrophage Diversity in Asthma, Shoobha S. Daftary, William J. Calhoun, and Nizar N. Jarjour Antigen Presentation in the Asthmatic Lung, Jonathan D. Edgeworth, Tak H. Lee, and Vanya Alasdair Gant Macrophage and Dendritic Cell Populations in Airway Tissues, Patrick G. Holt and Andrew S. McWilliam Fibroblasts and the Extracellular Matrix in Asthma, Anthony E. Redington, Patricia J. Sime, Peter H. Howarth, and Stephen T. Holgate Mediator Functions of Epithelial Cells, Katharine Knobil and David B. Jacoby Epithelium as a Target, Steven R. White and Alan R. Leff Airway Neuropeptides and Their Role in Inflammation, Peter J. Barnes Neuroimmune Interactions in Airway Inflammation, Karen E. Pedersen, Allen C. Myers, and Bradley J. Undem Microvascular-Epithelial Exudation of Bulk Plasma in Airway Defense, Disease, and Repair, Carl G. A. Persson, J. S. Erjefalt, M. Andersson, L. Greiff, and C. Svensson Neuroregulation of Mucosal Vasculature, James N. Baraniuk and Howard M. Druce Leukocyte-Endothelial Adhesion, Frank P. Bell, Brydon L. Bennett, and Anthony M. Manning Prostanoids, Arthur N. Freed and Steven R. Kleeberger Leukotrienes, Sven-Erik Dahlen Adenosine: Its Contribution to Our Understanding of Asthma, Gerrard D. Phillips and Stephen T. Holgate Chemotaxis and Mechanisms of Cell Migration, Janis K. Shute and Rabia Hidi Kinins, Bruce L. Zuraw and Sandra C. Christiansen The Early and Late Asthmatic Response to Allergen, Ketan K. Sheth and Robert F. Lemanske, Jr. Inflammatory Mechanisms of Aspirin-Sensitive Asthma, S. M. Shuaib Nasser and Tak H. Lee Inflammatory Mechanisms in Nocturnal Asthma, George C. Georges and Richard J. Martin Inflammatory Mediators and Exercise-Induced Asthma, Sandra D. Anderson Mechanisms of Airway Hyperresponsiveness, Paul M. O'Byrne Transcription Factors as Activators and Repressors of Gene Transcription: NK-RB and Glucocorticoid Receptors, Ian M. Adcock and Robert Newton Lower Airway Responses to Viruses, Philip G. Bardin, David J. Fraenkel, and Philip J. Bates

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