Principles of neural aging

著者

書誌事項

Principles of neural aging

edited by Sergio U. Dani, Akira Hori, Gerhard F. Walter

Elsevier, 1997

大学図書館所蔵 件 / 全9件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

The main purpose of this book is to understand the principles governing the longevity and loss of maintenance capacity of the nervous system. Neural aging is presented by specialists and even pioneers in their own fields, including evolutionary biology, genetics, biochemistry, biophysics, embryology, neurology, and pathology. It is thoroughly edited and illustrated, and organized in such a way as to fit, on the one hand the needs of a critical review and, on the other hand the aims of an introductory course on the biology of neural aging. With the progressive aging of the world population, there is an absolute need for a better understanding of the causes of longevity and the means to promote it. The considerations and hypotheses put forward in many chapters will stimulate research and thus be useful for those who intend to initiate or proceed in the fascinating field of neural aging.

目次

Contents in Brief: Preface. Acknowledgements. Contributors. Section I: General Theories of Aging: Part I: General Theories of Aging. Mechanisms of aging (S.U. Dani). Biophysical principles of aging (S.U. Dani). Mutation, evolution and aging (S.U. Dani, A.J.G. Simpson). General theories of aging: unification and synthesis (J.L. Graves). Part II: Proximate Mechanisms of Neural Aging. Structural regulation of gene expression: chromatin reorganization (A. Macieira-Coelho). Deletions of the mitochondrial genome and neurodegenerative diseases (S. Zullo, C.R. Merril). Molecular turnover and aging (S.U. Dani). The molecular biology of A|A deposition in Alzheimer disease (A.I. Bush, R.E. Tanzi). Internal disintegration of neurons by amyloid |A protein precursors (K. Yoshikawa). Section II: Ontogeny, Evolution and Neural Aging. Cell differentiation and ontogeny of the nervous system (S. Fujita). Ontogeny and evolution of the vertebrate central nervous system (S. Fujita). Evolution of brain size, morphological restructuring and longevity in early hominids (P.V. Tobias). Development of the human central nervous system (F. M 'ller, R. O'Rahilly). The limbic system as a model of cytoarchitectonical changes in the developing brain (I.N. Bogolepova). The metabolic basis of encephalization, prolonged life span, and the evolution of longevity (S.U. Dani). Evolution, secular changes and aging: how old is our brain? (S.U. Dani). Section III: Tissue and Cellular Changes. Neuron death: a developmental perspective (R. Linden). The aging human cerebral cortex: morphometry of areal differences and their functional meaning (H. Haug). Histological markers of neuronal aging and their meaning (S.U. Dani). Clinico-neuropathologic integration of dementia and Parkinson syndrome (neurofibrillary tangles and lewy bodies) (A. Hori). Changes in the white matter (J.E.H. Pittella). Nerve cell loss in the myenteric plexus (R.R. de Souza). Changes in the peripheral nervous system (T. Maisonobe, J-J. Hauw). Neoplasia as a model of neural aging (G.F. Walter). Dysregulation of glial cell apoptosis in the basis of neoplasia (D. Schiffer). Glial degeneration (K. Ikeda). Vascular changes (J.R.E. Bohl, A. Hori). Imaging the aging brain (H. Becker). Neuroimaging in the in vivo measurement of regional function in the aging brain (A.B. Newberg, A. Alavi). Aging in childhood (A. Hori). Section IV: Neural Aging, From Perception to Behavior. Geriatric psychiatry: the impact of neural science on mental health care of the aged (A. Meyer-Lindenberg, B. Gallhofer). Movement disorders (F. Blandini, C.Tassorelli, J.T. Greenamyre)

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