Extracellular matrix-cell interaction : molecules to diseases

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書誌事項

Extracellular matrix-cell interaction : molecules to diseases

edited by Yoshifumi Ninomiya, Bjorn Reino Olsen, Toshiro Ooyama

Japan Scientific Societies Press , Karger, c1998

  • : Tokyo
  • : Basel

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内容説明・目次

内容説明

The interaction of extracellular matrix (ECM) molecules with cells is important for cell differentiation and maintenance of tissue architecture, and elucidating these interactions will contribute to understanding the pathogenesis of many diseases involving ECM, such as rheumatoid arthritis, osteoarthrosis, or atherosclerosis. This book contains current information on the interaction between some representative extracellular molecules and cells. Chapters in the first half discuss the functional roles of such molecules or their receptors, including collagenase, fibrillins, laminin, aggrecan, tenascin-C, elastin, collagen, and PDGF receptors. The following chapters examine the regulation of expression of matrix-specific gene products and present disease-related analyses. Providing a basis for new therapeutic approaches to inflammatory or degenerative diseases of the connective tissue, the data compiled in this book will be valuable for a wide range of biomedical scientists.

目次

  • The role of collagenases in remodelling of the extracellular matrix - lessons from a targeted mutation in colla 1 that encodes resistance to collagenase cleavage, S.M. Krane and W.Zhao
  • two fibrillins, multiple fibrillinopathies, how many functions?, B.J. Dzamba et al
  • role of interchain disulfide-bonding in dimer-trimer switch during Laminin heterotrimer assembly, Y. Kitigawa et al
  • aggrecan - structure and role in genetic disorders, H. Watyana, Y. Yamada
  • extracellular matrix in tissue remodelling - tenascin-C as a modulator in cell-matrix interactions, M. Kusakabe and T. Sakakura
  • correlation of elastin expression and vascular smooth muscle cell proliferation in vitro, S. Tajima
  • topological distribution of collagen binding sites on fibroblasts cultured within collagen cells, M. Yamato and T. Hayashi
  • signalling pathways downstream of PDGF receptors involved in regulation of cell growth and motility, K. Yokote et al
  • Membranous structure immediately above, and tubular stromas in grooves between endothelial cell clusters
  • a novel helical filament model of hen tendon collagen fibril, N. Katsura and t. Ono
  • collagen gene expression in vascular smooth muscle cells - inhibition by B-Myb, K.E. Kypreos. G.E. Sonenshein
  • transcriptional regulation of Type-1 collagen genes, C. Rabe et al
  • expression of collagen IV genes and goodpasture antigens, Y. Sado et al
  • genetic determinants of extracellular matrix assembly and function, F. Ramirez et al
  • structural organization and pathological changes of the vitreous humour, R. Lu et al
  • chondonegic differentiation of mouse clonal cell line ATCD5 - differentiation-dependent expression of extracellular matrix genes, Y. Hiraki et al
  • type IIa procollagen may function to present bone morphogenetic proteins during endochondral bone formation
  • cartilage collagens and degenerative diseases of the joints and spine, T. Kimura
  • cartilage hypertrophy - isolation and characterization of upregulated, T.F. Linsenmayer, M. Nurminskaya
  • collagen-induced arthritis, L.K. Myers et al
  • perspectives, T. Ooyama.

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