The RNA world : the nature of modern RNA suggests a prebiotic RNA

Author(s)

• Gesteland, Raymond F.
• Cech, Thomas
• Atkins, John F. (John Fuller)

Bibliographic Information

The RNA world : the nature of modern RNA suggests a prebiotic RNA

edited by Raymond F. Gesteland, Thomas R. Cech, John F. Atkins

（Cold Spring Harbor monograph series, 37）

Cold Spring Harbor Laboratory Press, c1999

2nd ed

• : cloth
• : pbk

Note

Includes bibliographical references and index

Description and Table of Contents

Volume

: cloth ISBN 9780879695613

Description

As both an informational molecule and a catalyst, RNA may hold clues to the emergence of genetic self-replication and the origins of life. This revised and updated edition reviews the modern world of RNA and the light it sheds on a prebiotic era perhaps dominated by this versatile molecule.

Table of Contents

• The origins of RNA and RNA at the origin: before RNA and after - geophysical and geochemical constraints on molecular evolution
• prospects for understanding the origin of the RNA world
• the genomic tag hypothesis - what molecular fossils tell us about the evolution of tRNA
• probing RNA structure, function and history by comparative analysis
• recreating an RNA replicase
• did the RNA world exploit an expanded genetic alphabet?
• aminoacyl-tRNA synthetases and self-acylating ribozymes
• on the origin of the ribosome - coevolution of subdomains of tRNA and rRNA
• introns and the RNA world. How to build a functional RNA: the interactions that shape RNA structure
• small ribozymes
• the role of metal ions in RNA biochemistry
• building a catalytic active site using only RNA
• ribonuclease P
• the RNA folding problem. Transition to the RNP world: RNA interaction with small ligands and peptides
• RNA recognition by proteins
• group I and group II ribozymes as RNPs - clues to the past and guides to the future
• the growing world of small nuclear ribonucleoproteins
• splicing of precursors to mRNAs by the spliceosome
• tRNA splicing - an RNA world add-on or an ancient reaction?
• RNA editing - an evolutionary perspective
• telomerase
• dynamics of the genetic code. Appendices: structures of base pairs involving at least two hydrogen bonds
• schematic diagrams of secondary and tertiary structure elements
• reactions catalyzed by RNA and DNA enzymes
• visualization of elongation factor tu on the 70s E.coli ribosome
• the large ribosomal subunit from H. marismortui at 9 A resolution.

Volume

: pbk ISBN 9780879695897

Description

The origin of life is not the only topic covered in this book. The volume provides reviews of RNA function, each written by an expert in the field.

by "Nielsen BookData"

Details

• NCID: BA40016462
• ISBN:
  • 0879695617
  • 0879695897
• LCCN: 98041849
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Cold Spring Harbor, N.Y.
• Pages/Volumes: xxv, 709 p.
• Size: 24 cm
• Classification:
  • LCC : QP623
  • DC21 : 572.8/8
• Subject Headings:
  • LCSH : RNA -- Evolution
  • LCSH : Evolutionary genetics
• Parent Bibliography ID:
  • BA00291337