Enzymes, enzyme mechanisms, proteins, and aspects of NO chemistry
Author(s)
Bibliographic Information
Enzymes, enzyme mechanisms, proteins, and aspects of NO chemistry
（Comprehensive natural products chemistry / editors-in-chief, Sir Derek Barton, Koji Nakanishi ; executive editor, Otto Meth-Cohn, v. 5）
Elsevier, 1999
Available at / 54 libraries
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University Library for Agricultural and Life Sciences, The University of Tokyo図
613.64:B25:55010062643
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Note
Includes index
Description and Table of Contents
Description
Hardbound. This volume describes the dramatic advances in studies of the structure and function of enzymes which have led to an understanding of the rich chemistry used by nature to construct molecules and how the enzymes of natural products biosynthesis catalyze these reactions. Natural products are synthesized from simple precursors through a series of enzyme mediated reactions that are exquisitely selective and efficient. Questions about the mechanisms of these reactions and what features of enzyme catalytic sites are important for stabilizing transition states and reactive intermediates have been addressed by combining studies in mechanistic organic chemistry, structural biology, and molecular genetics. Except in rare instances, the enzymes of natural products biosynthesis are not found in abundance, and as a consequence, they are not readily available for study from natural sources. This situation has changed through the dramatic advances in gen
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