Enzymes, enzyme mechanisms, proteins, and aspects of NO chemistry
著者
書誌事項
Enzymes, enzyme mechanisms, proteins, and aspects of NO chemistry
（Comprehensive natural products chemistry / editors-in-chief, Sir Derek Barton, Koji Nakanishi ; executive editor, Otto Meth-Cohn, v. 5）
Elsevier, 1999
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注記
Includes index
内容説明・目次
内容説明
Hardbound. This volume describes the dramatic advances in studies of the structure and function of enzymes which have led to an understanding of the rich chemistry used by nature to construct molecules and how the enzymes of natural products biosynthesis catalyze these reactions. Natural products are synthesized from simple precursors through a series of enzyme mediated reactions that are exquisitely selective and efficient. Questions about the mechanisms of these reactions and what features of enzyme catalytic sites are important for stabilizing transition states and reactive intermediates have been addressed by combining studies in mechanistic organic chemistry, structural biology, and molecular genetics. Except in rare instances, the enzymes of natural products biosynthesis are not found in abundance, and as a consequence, they are not readily available for study from natural sources. This situation has changed through the dramatic advances in gen
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