Studies of aging
著者
書誌事項
Studies of aging
(Springer lab manual)
Springer-Verlag, c1999
大学図書館所蔵 全14件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This laboratory manual provides the researcher with a specific group of techniques, emphasising throughout hands-on information. A variety of protocols using molecular, cellular and physiological techniques are presented in detail and appropriate animal models have been selected for the study of ageing and ageing-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimers dementia and cardiovascular diseases, while techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage and mutations as well as techniques to study apoptosis for its role in cell ageing. XXXXXXXXX Neuer Text This lab manual provides hands-on protocols using molecular, cellular, and physiological techniques and the appropriate animal models for the study of aging and aging-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimers dementia and cardiovascular diseases. Techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage, as well as techniques to study apoptosis for its role in cell aging. A Springer Lab Manual
目次
A Molecular Methods: Introduction to Molecular Methods.- 1 Genotypic Selection of Age-Related DNA Rearrangements by PCR.- 2 Measurement of Antioxidants in Cutaneous Tissues.- Subprotocol 1: Skin Separation and Extraction.- Subprotocol 2: Lipophilic Antioxidants: Alpha-Tocopherol and Ubiquinol.- Subprotocol 3: Hydrophilic Antioxidants I: Ascorbate and Urate.- Subprotocol 4: Hydrophilic Antioxidants II: Glutathione.- Subprotocol 5: Antioxidant Enzymes - Catalase Activity.- Subprotocol 6: Antioxidant Enzymes - Glutathione Peroxidase Activity.- B Cellular Methods: Introduction to Cellular Methods.- 3 Cellular Aging / Replicative Senescence.- 4 Methods for Evaluating a Slice Culture Model of Alzheimer's Disease.- 5 Cell Death.- 6 Method for Studying the Migration of Aging Vascular Smooth Muscle Cells.- 7 Sensitized Chemiluminescence and Fluorescence Methods in Studies of Oxidative Stress.- C Animal Models: Introduction to Animal Models.- 8 How to Choose An Animal Model.- 9 Measuring Mortality and Reproduction in Large Cohorts of the Mediterranean Fruit Fly.- Subprotocol 1: Individuals and/or Pairs.- Subprotocol 2: Grouped Cages.- D Physiological Methods: Introduction to Physiological Methods.- 10 Methods for Evaluating in Vivo Rodent Models for Alzheimer's Disease.- 11 Dietary Restriction in Aging.- 12 Methods for the Evaluation of the Hypothalamo-Pituitary-Adrenoccortical Axis in the Aged Rat.- 13 Assessing Blood Replacement Fluids for Organ Preservation and Low Temperature Surgery.- 14 Brain Imaging in Normal and in Alzheimer's Disease.
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