The hepatitis C viruses
著者
書誌事項
The hepatitis C viruses
（Current topics in microbiology and immunology, 242）
Springer-Verlag, c2000
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.
目次
Studies of Non-A, Non-B Hepatitis and Characterization of the Hepatitis C Virus in Chimpanzees.- Hepatitis C Epidemiology.- Natural History and Disease Manifestations of Hepatitis C Infection.- Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties.-Internal Ribosome Entry Site-Mediated Translation in Hepatitis C Virus Replication.- Hepatitis C Virus Core Protein.- Folding, Assembly and Subcellular Localization of Hepatitis C Virus Glycoproteins.- Structure & Function of the Hepatitis C Virus Ns3-Ns4A Srine Proteinase.- Structure & Functions of Hepatitis C Virus NS3 Helicase.- Evading the Interferon Response.- Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase).- Systems to Culture Hepatitis C Virus.- Characterization of Hepatitis C Virus Infectious Clones in Chimpanzees.- Cell Mediated Immune Response to the Hepatitis C Virus.- Strategies & Prospects for Vaccination Against the Hepatitis C Viruses.- The GB Viruses.
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