Ion channels and disease : channelopathies

著者

• Ashcroft, Frances M.

書誌事項

Ion channels and disease : channelopathies

Frances M. Ashcroft

Academic Press, c2000

注記

Bibliography: p. 419-464

Includes index

内容説明・目次

内容説明

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology.

目次

From Gene to Protein How Channels Work Methods for Studying Ion Channels Voltage-Gated Na+ Channels Voltage-Gated K+ Channels Ca-Activated K+ Channels Inward Rectifier K+ Channels Voltage-Gated Ca2+ Channels Voltage-Gated Cl- Channels Cyclic Nucleotide-Gated Channels CFTR Epithelia Na+ Channels Ligand-Gated Ca2+ Channels ACh Receptor Channels Glutamate Receptor Channels Glycine Receptors GABA Receptors Water Channels Gap Junction Channels Antibodies to Ion Channels Ion Channels in Viruses Ion Channels as Lethal Agents A Miscellany of Ion Channels The Last Word

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BA45629356
• ISBN:
  • 0120653109
• LCCN: 98085618
• 出版国コード: uk
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: San Diego, Calif. ; London ; Tokyo
• ページ数/冊数: xxi, 481 p., [5] p. of plates
• 大きさ: 27 cm
• 分類:
  • DC21 : 571.64
• 件名:
  • LCSH : Ion channels