Human molecular genetics
著者
書誌事項
Human molecular genetics
BIOS Scientific Pub., 1999 , Wiley, 1999
2nd ed
- uk : pbk.
- us : pbk.
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
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us : pbk. ISBN 9780471330615
内容説明
This title provides introductory material on DNA and chromosomes and describes principles and applications of cloning and molecular hybridization, then presents a guide to the structure, evolution, and mutational instability of the human genome and human genes including mapping of the human genome.
- 巻冊次
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uk : pbk. ISBN 9781859962022
内容説明
Now completely rewritten, HMG2 guides students and researchers through the very latest developments in this most rapidly changing area of life science. The highly regarded structure of the best-selling first edition is retained, and a wealth of new data and features have been added to aid understanding of the principles of human molecular genetics: new material on cell types and the cell cycle, DNA mutation and repair, and comparative genomics and evolution an integrated approach to developmental genetics the latest Human Genome Project data including an assessment of the impact of complete genome sequences new section on how best to obtain the latest data from web-based resources a range of new figures, with many more in full color the early use of hierarchical figures and flow charts to introduce principles described fully in later chapters new two-column layout to improve clarity further references systematically updated HMG2 is the only book of choice for readers requiring an authoritative and integrated approach to human genetics.
目次
DNA structure and gene expression. Chromosomes in cells. Genes in pedigrees. Cell-based DNA cloning. Nucleic acid hybridization assays. PCR, DNA sequencing and in vitro mutagenesis. Organization of the human genome. Human gene expression. Instability of the human genome: mutation and DNA repair. Physical and transcript mapping. Genetic mapping of mendelian characters. Genetic mapping of complex characters. Genome projects. Our place in the tree of life. Identifying human disease genes. Molecular pathology. Genetic testing in individuals and populations. Cancer genetics. Complex diseases: theory and results. Studying human gene structure, expression and function using cultured cells and cell extracts. Genetic manipulation of animals. Gene therapy and other molecular genetic-based therapeutic approaches. Glossary. Index.
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