Chiral separations by chromatography
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書誌事項
Chiral separations by chromatography
American Chemical Society, c2000
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内容説明・目次
内容説明
The primary focus of this book is on developing or selecting suitable chromatographic methods for chiral separations. A large number of examples are given to assist in this process, including thin-layer, gas, HPLC, supercritical fluid, capillary electrophoresis, and membrane separations. It provides information on stereochemistry, TLC, GLC, and CE separation methods and detection; explores the importance of preparative separations; and illustrates the stereoisomeric
composition of chemical compounds of pharmaceutical significance. There is discussion of regulations and requirements as they apply to the development of pharmaceutical compounds, and a detailed section on HPLC methods.
目次
- Chapter 1. An overview
- Chirality and biological activity
- Chiral separations
- Chiral stationary phases
- Modern CSP design
- Preparative separations
- Regulatory perspectives
- Chapter 2. Perspectives on Evaluation of Stereoisomers as Drug Candidates
- Marketing status of single isomers
- Development of single enantiomers
- Pharmacokinetics
- Detoxification
- Stability
- Industrial perspectives
- Regulatory guidelines
- Chapter 3. Review of Stereochemistry
- Brief history
- Stereoisomerism
- Classification
- Nomenclature
- Resolution
- Enantiopurity
- Determination of absolute configuration
- Chapter 4. Separation Methods
- Thin layer chromatography
- Gas chromatography
- High pressure liquid chromatography
- Supercritical fluid chromatography
- Capillary electrophoresis
- Chapter 5. Detection Methods
- Detectors for TLC
- Detectors for GC
- Detectors for HPLC
- Specific detectors for chiral compounds
- Chapter 6. Desirable Features of Chiral Stationary Phases
- Desirable features
- Types of CSPs
- Comparison of various CSPs
- Chapter 7. Understanding Chiral Chromatography
- Enantioselective interactions
- Chromatographic enantioselectivity
- Inclusion
- Transition metal complexes
- Separations on protein columns
- Molecular modeling
- Chapter 8. Method Development
- Stereoisomeric Interactions
- Chromatographic methods
- Chromatographic methods
- Modes of separation in HPLC
- Chromatography of diastereomeric derivatives
- Enantiomeric resolution using chiral mobile-phase additives
- Enantiomeric resolution using chiral stationary phases
- Computerized methods
- Chapter 9. Preparative Separations
- Displacement chromatography
- Elution chromatography
- Chapter 10. Method Selection and Selected Applications
- Where to start?
- Study the molecule
- Which method to use?
- High pressure liquid chromatography
- Gas chromatography
- Supercritical fluid chromatography (SFC)
- Capillary electrophoresis (CE)
- Comparative separations
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