HIV-1 : molecular biology and pathogenesis
著者
書誌事項
HIV-1 : molecular biology and pathogenesis
（Advances in pharmacology / edited by Silvio Garattini [and] Parkhurst A. Shore, v. 48,
Academic Press, c2000
- Viral mechanisms
- Clinical applications
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Viral mechanisms5200045353,
Clinical applications5200046003, 2(v.49)5200046003, 1(v.48)5200045353 -
Viral mechanisms493.878||H78||1100081454,
Clinical applications493.878||H78||2100084169 -
Viral mechanisms499.05||A16||4800F0040,
Clinical applications499.05||A16||4900F0042 -
Viral mechanisms491.5||H78||4820022212,
Clinical applications491.5||H78||4920022211 OPAC
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注記
Includes bibliographies and indexes
内容説明・目次
- 巻冊次
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Viral mechanisms ISBN 9780120329496
内容説明
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia.
目次
HIV RNA Packaging and Lentivirus-Based Vectors, A.M.L. Lever.
Multiple Biological Roles Associated with the Repeat (R) Region of the HIV-1 RNA Genome, B. Berkhout.
HIV Accessory Proteins: Multifunctional Components of a Complex System, S. Bour and K. Strebel.
Role of Chromatin in HIV-1 Transcriptional Regulation, C. Van Lint.
NF-kB and HIV: Linking Viral and Immune Activation, A.B. Rabson and H.-C. Lin.
Tat as a Transcriptional Activator and a Potential Therapeutic Target for HIV-1, A. Gatignol and K.-T. Jeang.
From the Outside In: Extracellular Activities of HIV Tat, D. Noonan and A. Albini.
Rev Protein and Its Cellular Partners, J. Kjems and P. Askjaer.
HIV-1 Nef: A Critical Factor in Viral-Induced Pathogenesis, A.L. Greenway, G. Holloway, and D.A. McPhee.
Nucleocapsid Protein of Human Immunodeficiency Virus as a Model Protein with Chaperoning Functions and as a Target for Antiviral Drugs, J.-L. Darlix, G. Cristofari, M. Rau, C. Pechoux, L. Berthoux, and B. Roques.
Bioactive CD4 Ligands as Pre- and/or Postbinding Inhibitors of HIV-1, L. Briant and C. Devaux.
- 巻冊次
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Clinical applications ISBN 9780120329502
内容説明
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia.
目次
HIV Therapeutics: Past, Present, and Future, O. Abu-Ata, J. Slim, G. Perez, and S.M. Smith.
HIV Drug Resistance and Viral Fitness, F. Clavel and F. Mammano.
Inhibitors of HIV-1 Reverse Transcriptase, M.A. Parniak and N. Sluis-Cremer.
HIV-I Protease: Maturation, Enzyme Specificity, and Drug Resistance, J.M. Louis, I.T. Weber, J. Toezser, G.M. Clore, and A.M. Gronenborn.
HIV-I Integrase Inhibitors: Past, Present, and Future, N. Neamati, C. Marchand, and Y. Pommier.
Selection of HIV Replication Inhibitors: Chemistry and Biology, S. Hwang, N. Tamilarasu, and T.M. Rana.
Therapies Directed against the Rev Axis of HIV Autoregulation, A.I. Dayton and M.J. Zhang.
HIV-I Gene Therapy: Promise for the Future, R. Dornburg and R.J. Pomerantz.
Assessment of HIV Vaccine Development: Past, Present, and Future, M.W. Cho.
HIV-I-Associated Central Nervous System Dysfunction, F.C. Krebs, H. Ross, J. McAllister, and B. Wigdahl.
Molecular Mechanisms of Human Immunodeficiency Virus Type I Mother-Infact Transmission, N. Ahmad.
Molecular Epidemiology of HIV-I: An Example of Asia, M.-Y. Chen and C.-N. Lee.
Simian Immunodeficiency Virus Infection of Monkeys as a Model System for the Study of AIDS Pathogenesis, Treatment and Prevention, V.M. Hirsch and J.D. Lifson.
Animal Models for AIDS Pathogenesis, J.J. Trimble, J.R. Salkowitz, and H.W. Kestler.
Index.
Contents of Previous Volumes.
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