Antiviral agents : advances and problems

著者

    • Jucker, Ernst

書誌事項

Antiviral agents : advances and problems

edited by Ernst Jucker

(Progress in drug research / edited by Ernest Jucker, Special topic ; [1])

Birkhäuser, c2001

タイトル別名

Antiviral agents : special topic

Antiviral agents : advances and problems : special topic

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注記

"With this first Special Topic volume, composed of contributions from the monograph series Progress in Drug Researach ... "--back cover

Authors: Shijun Ren and Eric J. Lien ... [et al.]

内容説明・目次

内容説明

In the treatment of infections caused by rapidly mutating viruses like human immunodeficiency virus (HIV), combination therapy with multiple drugs act- ing by different mechanisms offers several advantages over monotherapy. It may provide: synergistic effect, possible reduction of dosages and side-effects, and reduction of the chance of drug resistance. In the past few years, hun- dreds of HIV protease inhibitors have been synthesized and tested in order to overcome the limitations of reverse transcriptase inhibitors like zidovudine and others. In this review, emphasis is placed on the development of HIV pro- tease inhibitors as antiviral agents against HIY, and structure-activity rela- tionship analysis of saquinavir and related compounds. Limitations of some protease inhibitors and ways to overcome the shortcomings are presented. Among these many protease inhibitors five have been marketed during 1995-1999. They are saquinavir, ritonavir, indinavir, nelfinavir and ampre- navir. Their different structural features, important physicochemical, phar- macokinetic and clinical profiles are presented in a table form for easy com- parison. It is hoped that in the future new drugs based on additional mech- anisms can be developed for the treatment of AIDS. Contents 4 1 Introduction ...HIV protease as a target for chemotherapy ...2 5 Design of protease inhibitors ...3 5 Basis of rational design of HIV protease inhibitors ...3.1 5 New development of HIV protease inhibitors ...6 3.2 HIV protease inhibitors on the market ...20 4 20 4.1 SAR of saquinavir and related compounds ...

目次

Development of HIV protease inhibitors: A survey.- Anti-influenza drugs and neuraminidase inhibitors.- Recent advances in prevention and treatment of hepatitis C virus infections.- Drug discovery and development of antiviral agents for the treatment of chronic hepatitis B virus infection.- Current and potential therapies for the treatment of herpesvirus infections.- Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections.

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関連文献: 1件中  1-1を表示

  • Progress in drug research

    edited by Ernest Jucker

    Birkhäuser 1998-

    v. 50 , v. 51 , v. 52 , v. 53 , v. 54 , v. 55 , v. 56 , v. 57 , v. 58 , v. 59 , Special topic , v. 60 , v. 61

    所蔵館9館

詳細情報

  • NII書誌ID(NCID)
    BA54881174
  • ISBN
    • 3764365471
  • 出版国コード
    gw
  • タイトル言語コード
    eng
  • 本文言語コード
    eng
  • 出版地
    Basel
  • ページ数/冊数
    [viii], 258 p.
  • 大きさ
    24 cm
  • 親書誌ID
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