Amino acid and peptide synthesis

Bibliographic Information

Amino acid and peptide synthesis

John Jones

(Oxford chemistry primers, 7)

Oxford University Press, 2002

2nd ed

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Note

Includes bibliographical references (p. [89]) and index

"Oxford higher education"

Description and Table of Contents

Description

The study of amino acids and peptides is becoming increasingly important to chemists becuase of the growing overlap of mainstream organic chemistry with bioorganic chemistry and biochemistry. This introductory text begins with a brief survey of the role and diversity of amino acids, peptides, and proteins in nature, and goes on to describe and explain the principal methods of chemical synthesis. With its emphasis on chemical principles and strategies rather than detailed technical matters, the book will be essential reading for all students of chemistry and biochemistry with an interest in this important field. This second edition contains extensive additions and adjustments, to present a completely up-to-date account of the chemical essentials of mainstream peptide synthesis.

Table of Contents

  • 1. Introduction
  • 2. a-Amino acid synthesis
  • 3. a-Amino protection
  • 4. a-Carboxy protection
  • 5. Peptide bond formation
  • 6. Residue-specific considerations
  • 7. Strategy and tactics
  • 8. Solution peptide synthesis
  • 9. Solid phase peptide synthesis
  • 10. GFP, a tour de force
  • Appendix A Abbreviations and their use
  • Appendix B Further reading and general sources
  • Index

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