CiNii Books - Fitzpatrick's dermatology in general medicine

For decades, thousands of clinicians have turned to Fitzpatrick's Dermatology in General Medicine for reliable help with making prompt and accurate evaluations of skin disorders, judicious use of laboratory procedures and appropriate treatment decisions.The 6th Edition continues to integrate the basic and clinical sciences and, like its predecessors, is encyclopaedic in its scope. The two volumes contain 280 chapters covering all aspects of the science and clinical care of the skin in both health and disease. Careful editing ensures ease of use and readability.Content has been updated and expanded throughout and many new chapters, on topics ranging from photo-immunology to retinoids and botox, have been added. It represents the expertise of over 300 of the world's most respected specialists - 50 of whom are new to this edition and provide a fresh and valuable perspective.In addition, 2,300 outstanding, full-colour photographs and hundreds of timesaving, information-at-a-glance tables enhance the text while scores of references facilitate further in-depth research.

Table of Contents

PART ONEIntroductionSection 1General Considerations1.Where Have We Come From? Karl Holubar and Stella Fatovic-Ferencic2.The Epidemiology and Burden of Skin Disease Martin A. Weinstock and Mary-Margaret ChrenSection 2Clinical-Pathologic Correlations of Skin Lesions: Approach to Diagnosis3.The Structure of Skin Lesions and Fundamentals of Diagnosis Margaret I. Stewart, Jeffrey D. Bernhard, Thomas G. Cropley, and Thomas B. Fitzpatrick4.Basic Pathologic Reactions of the Skin Klaus Wolff, Abdul-Ghani Kibbi, and Martin C. Mihm, Jr.PART TWOBiology and Development of SkinSection 3Structure and Development of Skin5.Genetics in Relation to the Skin Lowell A. Goldsmith and Ervin H. Epstein, Jr.6.The Structure and Development of Skin David H. Chu, Anne R. Haake, Karen Holbrook, and Cynthia A. LoomisSection 4Biology and Function of Epidermis and Appendages7.Epidermal Cell Kinetics, Epidermal Differentiation, and Keratinization Arash Kimyai-Asadi, Ming H. Jih, and Irwin M. Freedberg8.Biology of Eccrine and Apocrine Sweat Glands Lowell A. Goldsmith9.Skin As an Organ of Protection Peter M. Elias, Kenneth R. Feingold, and Joachim W. Fluhr10.Thermoregulation C. Bruce Wenger11.Biology of Melanocytes Ruth Halaban, Daniel N. Hebert, and David E. Fisher12.Biology of Hair Follicles Robert M. Lavker, Arthur Bertolino, Irwin M. Freedberg, and Tung-Tien Sun13.Biology of Nails Antonella Tosti and Bianca Maria PiracciniSection 5Biology of Extracellular Matrix, Blood Vessels, and Nerves14.Collagen Jouni Uitto, Leena Pulkkinen, and Mon-Li Chu15.Elastic Fibers Jouni Uitto and Mon-Li Chu16.Basement Membranes Leena Bruckner-Tuderman17.The Role of Extracellular Matrix Metalloproteinases in Connective Tissue Remodeling Jo L. Seltzer and Arthur Z. Eisen18.Proteoglycans and Glycosaminoglycans of Skin Richard L. Gallo and Janet M. Trowbridge19.Endothelium Peter Petzelbauer, Jeffrey S. Schechner, and Jordan S. Pober20.Neurobiology of the Skin Franz J. Legat, Cheryl A. Armstrong, Thomas Scholzen, John E. Olerud, Nigel W. Bunnett, Thomas A. Luger, and John C. Ansel21.Mechanisms of Cutaneous Wound Repair Vincent FalangaSection 6Cellular and Molecular Biology of Inflammation, Repair, and Carcinogenesis22.Innate Immunity and the Skin Jenny Kim and Robert L. Modlin23.The Skin: An Immunologic Barrier Georg Stingl, Dieter Maurer, Conrad Hauser, and Klaus Wolff24.Influence of the HLA System on Disease Susceptibility Madeleine Duvic25.Immunoglobulin Structure and Function Lela A. Lee26.Cytokines Ifor R. Williams, Benjamin E. Rich, and Thomas S. Kupper27.Chemokines Sam T. Hwang28.Lymphocytes Robert L. Modlin29.Regulation of the Production and Activation of Neutrophils Shireen V. Guide and Steven M. Holland30.Regulation of the Production and Activation of Eosinophils Adrienne Rencic and Lisa A. Beck31.Regulation of the Production and Activation of Basophils John T. Schroeder32.The Molecular and Cellular Biology of the Mast Cell Fred H. Hsieh, Clifton O. Bingham, III, and K. Frank Austen33.Human Complement System Irma Gigli34.Eicosanoids Alice P. Pentland35.Cellular Hypersensitivity and DNA Repair Kenneth H. Kraemer36.Carcinogenesis: Chemical Andrzej Dlugosz and Stuart H. Yuspa37.Oncogenes and Viral Carcinogenesis Douglas R. Lowy38.Carcinogenesis: Ultraviolet Radiation Margaret L. Kripke and Honnavara N. Ananthaswamy39.Photoimmunology Richard D. GransteinPART THREEDisorders Presenting in the Skin and Mucous MembranesSection 7Noncutaneous Manifestations of Skin Diseases40.Psychological Aspects of Skin Disease Thomas W. Koenig, Sylvia Garnis-Jones, Adrienne Rencic, and Francisco A. Tausk41.Pathophysiology and Clinical Aspects of Pruritus Malcolm W. GreavesSection 8Epidermis: Disorders of Persistent Inflammation, Cell Kinetics, and Differentiation42.Psoriasis Enno Christophers and Ulrich Mrowietz43.Psoriatic Arthritis Robert Winchester44.Exfoliative Dermatitis Ming H. Jih, Arash Kimyai-Asadi, and Irwin M. Freedberg45.Pityriasis Rubra Pilaris Lowell A. Goldsmith and Howard P. Baden46.Pityriasis Rosea Alf Bjoernberg and Eva Tegner47.Parapsoriasis Gary S. Wood and Chung-Hong Hu48.Pityriasis Lichenoides Mazen S. Daoud and Mark R. Pittelkow49.Lichen Planus Mazen S. Daoud and Mark R. Pittelkow50.Lichen Nitidus Mazen S. Daoud and Mark R. Pittelkow51.Ichthyosiform Dermatoses John J. DiGiovanna52.The Inherited Keratodermas of Palms and Soles Howard P. Stevens, David P. Kelsell, and Irene M. Leigh53.Ectodermal Dysplasias Virginia P. Sybert54.Darier-White Disease (Keratosis Follicularis) and Acrokeratosis Verruciformis Lowell A. Goldsmith and Howard P. Baden55.Transient Acantholytic Dermatosis (Grover Disease) Peter J. Heenan and Christopher J. Quirk56.Porokeratosis Elisabeth Ch. Wolff-Schreiner57.Kyrle Disease and Other Perforating Disorders Elisabeth Ch. Wolff-SchreinerSection 9Epidermis: Disorders of Epidermal Cohesion-Vesicular and Bullous Disorders58.Erythema Multiforme, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis Peter O. Fritsch and Ramon Ruiz-Maldonado59.Pemphigus John R. Stanley60.Paraneoplastic Pemphigus Grant J. Anhalt and H. Carlos Nousari61.Bullous Pemphigoid John R. Stanley62.Cicatricial Pemphigoid Kim B. Yancey63.Linear IgA Dermatosis and Chronic Bullous Disease of Childhood Caroline L. Rao and Russell P. Hall, III64.Pemphigoid Gestationis (Herpes Gestationis) Stephen I. Katz65.Inherited Epidermolysis Bullosa M. Peter Marinkovich, Paul A. Khavari, G. Scott Herron, and Eugene A. Bauer66.Epidermolysis Bullosa Acquisita David T. Woodley, Mei Chen, W. Ray Gammon, and Robert A. Briggaman67.Dermatitis Herpetiformis Stephen I. Katz68.Familial Benign Pemphigus (Hailey-Hailey Disease) Robin A.C. Graham-Brown69.Subcorneal Pustular Dermatosis (Sneddon-Wilkinson Disease) Herbert Hoenigsmann, Franz Trautinger, and Klaus Wolff70.Pustular Eruptions of Palms and Soles Enno Christophers and Ulrich MrowietzSection 10Disorders of Epidermal Appendages and Related Disorders 71.Hair Disorders Elise A. Olsen72.Nails Robert Baran and Antonella Tosti73.Diseases of the Sebaceous Glands Diane M. Thiboutot and John S. Strauss74.Rosacea Gerd Plewig and Thomas Jansen75.Perioral Dermatitis R. Marks76.Disorders of the Eccrine Sweat Glands Lowell A. Goldsmith77.Disorders of the Apocrine Sweat Glands Mazen S. Daoud and Charles H. Dicken78.Follicular Syndromes with Inflammation and Atrophy Peter O. FritschSection 11Epidermal and Appendageal Tumors 79.Epithelial Precancerous Lesions Karynne O. Duncan and David J. Leffell80.Squamous Cell Carcinoma Douglas Grossman and David J. Leffell81.Basal Cell Carcinoma John A. Carucci and David J. Leffell82.Basal Cell Nevus Syndrome Ervin H. Epstein, Jr.83.Keratoacanthoma Lorenzo Cerroni and Helmut Kerl84.Benign Epithelial Tumors Shane G. Silver and Vincent C.Y. Ho85.Appendage Tumors of the Skin Steven Kaddu and Helmut Kerl86.Cutaneous Neuroendocrine Carcinoma: Merkel Cell Carcinoma Helmut Kerl and Rainer Hofmann-Wellenhof87.Mammary and Extramammary Paget's Disease S.M. ConnollySection 12Disorders of Melanocytes88.Normal Skin Color and General Considerations of Pigmentary Disorders Thomas B. Fitzpatrick and Jean-Paul Ortonne89.Albinism Philippe Bahadoran, Jean-Paul Ortonne, Richard A. King, and William S. Oetting90.Hypomelanoses and Hypermelanoses Jean-Paul Ortonne, Philippe Bahadoran, Thomas B. Fitzpatrick, David B. Mosher, and Yoshiaki Hori91.Benign Hyperplasias and Neoplasias of Melanocytes James M. Grichnik, Arthur R. Rhodes, and Arthur J. Sober92.Atypical Melanocytic Nevi Hensin Tsao and Arthur J. Sober93.Neoplasms: Cutaneous Melanoma Richard G.B. Langley, Raymond L. Barnhill, Martin C. Mihm, Jr., Thomas B. Fitzpatrick, and Arthur J. SoberSection 13Inflammatory and Neoplastic Disorders of the Dermis94.Acute Febrile Neutrophilic Dermatosis (Sweet's Syndrome) Herbert Hoenigsmann, Philip R. Cohen, and Klaus Wolff95.Erythema Elevatum Diutinum Stephen I. Katz96.Eosinophils in Cutaneous Diseases Kristin M. Leiferman, Margot S. Peters, and Gerald J. Gleich97.Granuloma Faciale Walter H.C. Burgdorf98.Pyoderma Gangrenosum Klaus Wolff and Georg Stingl 99.Erythema Annulare Centrifugum and Other Figurate Erythemas Walter H.C. Burgdorf100.Granuloma Annulare Mark V. Dahl101.Malignant Atrophic Papulosis (Degos' Disease) Louis Dubertret102.Fibrous Lesions of Dermis and Soft Tissue Christopher R. Shea and Victor G. Prieto103.Vascular Anomalies and Tumors of Skin and Subcutaneous Tissues Suzanne Virnelli Grevelink and John Butler Mulliken104.Kaposi's Sarcoma Klemens Rappersberger, Georg Stingl, and Klaus Wolff105.Anetoderma and Other Atrophic Disorders of the Skin Walter H.C. Burgdorf106.Ainhum and Pseudoainhum Walter H.C. Burgdorf107.Neoplasias and Hyperplasias of Neural and Muscular Origin Steffen Albrecht108.Acquired Perforating Disorders Mark LebwohlSection 14Disorders of Subcutaneous Tissue 109.Panniculitis Michael J. Camilleri and W.P. Daniel Su110.Lipodystrophy Ervin H. Epstein, Jr.111.Neoplasms of the Subcutaneous Fat Karl H. AndersSection 15Disorders of the Mucocutaneous Integument112.Biology and Pathology of the Oral Mucosa Jonathan A. Ship, Joan Phelan, and A. Ross Kerr113.Diseases and Disorders of the Male Genitalia Richard Allen Johnson114.Diseases and Disorders of the Anogenitalia of Females Libby EdwardsSection 16Cutaneous Changes in Disorders of Altered Reactivity115.Genetic Immunodeficiency Diseases Amy S. Paller116.Urticaria and Angioedema Nicholas A. Soter and Allen P. Kaplan117.Angioedema Associated with Complement Abnormalities Irma Gigli and Fred S. Rosen118.Graft-versus-Host Disease Thomas D. Horn119.Mucocutaneous Manifestations of the Non-HIV-Infected Immunosuppressed Host Andrew Blauvelt120.Allergic Contact Dermatitis Donald V. Belsito121.Autosensitization Dermatitis122.Atopic Dermatitis (Atopic Eczema) Donald Y.M. Leung, Lawrence F. Eichenfield, and Mark Boguniewicz123.Nummular Eczema and Lichen Simplex Chronicus/Prurigo Nodularis Nicholas A. Soter124.Seborrheic Dermatitis Gerd Plewig and Thomas Jansen125.Vesicular Palmoplantar Eczema Alexa Boer KimballSection 17Skin Changes Due to Mechanical and Physical Factors126.Cold Injuries Gerald Pierard, Isabelle Fumal, and Claudine Pierard-Franchimont127.Evaluation and Management of the Thermally Injured Patient Robert Sheridan128.Radiobiology and Radiotherapy of Skin Diseases Frederick D. Malkinson and Renato G. Panizzon129.Skin Problems in Amputees and Ostomates Calum C. Lyon and Michael H. Beck130.Corns and Calluses Thomas M. DeLauro131.Sports Dermatology Dirk M. Elston132.Decubitus (Pressure) Ulcers and Venous Ulcers Joel M. Gelfand and David J. MargolisSection 18Photomedicine133.Photophysics, Photochemistry, and Photobiology< Irene E. Kochevar and Charles R. Taylor134.Acute and Chronic Effects of Ultraviolet Radiation on the Skin Susan L. Walker, John L.M. Hawk, and Antony R. Young135.Abnormal Responses to Ultraviolet Radiation: Idiopathic, Probably Immunologic, and Photoexacerbated John L.M. Hawk, Paul G. Norris, and Herbert Hoenigsmann136.Abnormal Responses to Ultraviolet Radiation: Photosensitivity Induced by Exogenous Agents Henry W. LimSection 19Disorders Due to Drugs and Chemical Agents137.Occupational Skin Disease James S. Taylor and Apra Sood138.Cutaneous Reactions to Drugs Neil H. Shear, Sandra R. Knowles, John R. Sullivan, and Lori Shapiro139.Mucocutaneous Complications of Antineoplastic Therapy James E. Fitzpatrick140.Cutaneous Reactions to Cytokines and Growth Factors Maria L. Chanco Turner141.Cutaneous Manifestations of Drug Abuse Miguel R. SanchezPART FOURDermatology and MedicineSection 20Skin Changes across the Span of Life142.Skin Changes and Diseases in Pregnancy Thomas J. Lawley and Kim B. Yancey143.Neonatal, Pediatric, and Adolescent Dermatology Mary Wu Chang and Seth J. Orlow144.Aging of Skin Mina Yaar and Barbara A. GilchrestSection 21Skin Lesions in Nutritional, Metabolic, and Heritable Disorders145.Cutaneous Changes in Nutritional Disease David S. Nieves and Lowell A. Goldsmith146.Acrodermatitis Enteropathica and Other Zinc-Deficiency Disorders Kenneth H. Neldner147.Cutaneous Changes in Errors of Amino Acid Metabolism: Tyrosinemia II, Phenylketonuria, Argininosuccinic Aciduria, and Alkaptonuria Lowell A. Goldsmith148.Amyloidosis of the Skin Stephen Michael Breathnach149.The Porphyrias David R. Bickers and Jorge Frank150.Xanthomatoses and Lipoprotein Disorders Lowell A. Goldsmith151.Fabry Disease: -Galactosidase A Deficiency (Angiokeratoma Corporis Diffusum Universale) Robert J. Desnick and Maryam Banikazemi152.Lipoid Proteinosis Ch. M. Lapiere153.Cutaneous Mineralization and Ossification John S. Walsh and Janet A. Fairley154.Heritable Disorders of Connective Tissue with Skin Changes Richard J. Wenstrup and Huiquan Zhao155.Heritable Diseases with Increased Sensitivity to Cellular Injury Kenneth H. Kraemer<34>Section 22Skin Manifestations of Bone Marrow or Blood Element Disorders156.Hematologic Diseases Warren W. Piette157.Cutaneous T Cell Lymphomas Jo-Ann Latkowski and Peter W. Heald158.Other Systemic Lymphomas with Skin Infiltration Wolfram Sterry and J. Marcus Muche159.Inflammatory Diseases That Simulate Lymphomas: Cutaneous Pseudolymphomas Gary S. Wood160.Langerhans Cell Histiocytosis Ruggero Caputo161.Cutaneous Nonhistiocytoses X Ruggero Caputo162.Multicentric Reticulohistiocytosis Karl Holubar163.The Mastocytosis Syndrome Dean D. MetcalfeSection 23Skin Manifestations of Gastrointestinal and Renal Disorders164.The Skin and Disorders of the Alimentary Tract and the Hepatobiliary System Graham A. Johnston and Robin A.C. Graham-Brown165.Cutaneous Changes in Renal Disorders Susan Sweeney and Thomas G. CropleySection 24Skin Manifestations of Disorders of the Cardiovascular and Pulmonary Systems166.Cutaneous Aspects of Cardiopulmonary Disease Andrew G. Franks, Jr., and Victoria P. Werth167.Cutaneous Changes in Peripheral Vascular Disease Jay D. Coffman and Robert T. EberhardtSection 25Skin Manifestations of Alterations and Disorders of the Endocrine System168.Diabetes Mellitus Jennifer L. Bub and John E. Olerud169.Cutaneous Manifestations of Other Endocrine Diseases Janie M. Leonhardt and Warren R. Heymann170.Cutaneous Changes in the Flushing Disorders and the Carcinoid Syndrome Eva A. Hurst and Michael P. HeffernanSection 26Skin Manifestations of Rheumatologic Multisystem Diseases171.Lupus Erythematosus Melissa I. Costner and Richard D. Sontheimer172.Dermatomyositis Richard D. Sontheimer and Melissa I. Costner173.Scleroderma Benjamin D. Yu and Arthur Z. Eisen174.Systemic Necrotizing Arteritis Brian F. Mandell and Gary S. Hoffman175.Cutaneous Necrotizing Venulitis Nicholas A. Soter176.Pigmented Purpuric Dermatoses Theresa Schroeder177.Cryoglobulinemia and Cryofibrinogenemia Lynn A. Cornelius and Thomas J. Lawley178.Relapsing Polychondritis Stephen I. Katz179.Rheumatoid Arthritis, Rheumatic Fever, and Gout Carlin B. Hollar and Joseph L. Jorizzo180.Sjoegren's Syndrome H. Carlos Nousari and Thomas T. Provost181.Raynaud's Phenomenon John H. Klippel182.Reiter's Syndrome Robert WinchesterSection 27Skin Manifestations of Diseases in Other Organ Systems183.Sarcoidosis Irwin M. Braverman184.Cutaneous Manifestations of Internal Malignant Disease: Cutaneous Paraneoplastic Syndromes David I. McLean and Harley A. Haynes185.Acanthosis Nigricans Karen R. Houpt and Ponciano D. Cruz, Jr.186.Scleredema Raul Fleischmajer187.Papular Mucinosis Raul Fleischmajer188.Neurocutaneous Diseases Rudolf Happle189.Tuberous Sclerosis Complex Amy S. Paller and Lowell A. Goldsmith190.The Neurofibromatoses Eniko K. Pivnick and Vincent M. Riccardi191.Ataxia-Telangiectasia Amy S. Paller192.Behcet's Disease Rachel A. Garton and Joseph L. JorizzoPART FIVEDiseases Due to Microbial Agents, Infestations, Bites, and StingsSection 28Bacterial Diseases with Cutaneous Involvement193.General Considerations of Bacterial Diseases Morton N. Swartz and Arnold N. Weinberg194.Pyodermas: Staphylococcus Aureus, Streptococcus, and Other Gram-Positive Bacteria Peter K. Lee, Matthew T. Zipoli, Arnold N. Weinberg, Morton N. Swartz, and Richard A. Johnson195.Staphylococcal Scalded Skin Syndrome Steven D. Resnick and Peter M. Elias196.Soft Tissue Infections: Erysipelas, Cellulitis, Gangrenous Cellulitis, and Myonecrosis Arnold N. Weinberg, Morton N. Swartz, Hensin Tsao, and Richard A. Johnson197.Gram-Negative Coccal and Bacillary Infections Arnold N. Weinberg and Morton N. Swartz198.Bartonellosis Timothy G. Berger and Francisco Bravo199.Miscellaneous Bacterial Infections with Cutaneous Manifestions Morton N. Swartz and Arnold N. Weinberg200.Tuberculosis and Other Mycobacterial Infections Gerhard Tappeiner and Klaus Wolff201.Actinomycosis, Nocardiosis, and Actinomycetoma Mauricio Goihman-Yahr, Michael M. McNeil, and June M. Brown 202.Leprosy Thomas H. Rea and Robert L. Modlin203.Lyme Borreliosis Eva Asbrink and Anders Hovmark204.Kawasaki Syndrome Donald Y.M. Leung and Anne W. LuckySection 29Fungal Diseases with Cutaneous Involvement205.Superficial Fungal Infection: Dermatophytosis, Onychomycosis, Tinea Nigra, Piedra Michael M. Nelson, Ann G. Martin, and Michael P. Heffernan206.Yeast Infections: Candidiasis, Pityriasis (Tinea) Versicolor Alison S. Klenk, Ann G. Martin, and Michael P. Heffernan207.Deep Fungal Infections R.J. HaySection 30Viral and Rickettsial Diseases208.Viral Diseases: General Considerations Douglas R. Lowy209.Rubella (German Measles) Stephen E. Gellis210.Measles Louis Z. Cooper211.Hand-Foot-and-Mouth Disease Raphael Dolin212.Herpangina David A. Sirois213.Erythema Infectiosum and Parvovirus B19 Infection Karen Wiss214.Herpes Simplex Adriana R. Marques and Stephen E. Straus215.Varicella and Herpes Zoster Stephen E. Straus, Kenneth E. Schmader, and Michael N. Oxman216.Cytomegalovirus Infection Francesco Drago and Alfredo Rebora217.Epstein-Barr Virus Infections Jeffrey I. Cohen218.Human Herpesvirus 6 and 7 Infections and Exanthem Subitum (Roseola Infantum or Sixth Disease) Sandy Tsao219.Smallpox and Complications of Smallpox Vaccination Vincent A. Fulginiti220.Orf (Contagious Pustular Dermatitis, Contagious Ecthyma) Renee R. Snyder and Dayna G. Diven221.Molluscum Contagiosum Douglas R. Lowy and Elliot J. Androphy222.Milker's Nodules Douglas R. Lowy223.Warts Douglas R. Lowy and Elliot J. Androphy224.Human Retroviral Disease: Human T-Lymphotropic Viruses Erwin Tschachler, Marvin S. Reitz, Jr., and Genoveffa Franchini225.Cutaneous Manifestations of Human Immunodeficiency Virus Disease Richard Allen Johnson226.Prions and the Skin Johannes Pammer and Erwin Tschachler227.The Rickettsioses and Ehrlichioses Justin J. Green and Warren R. HeymannSection 31Sexually Transmitted Diseases228.Syphilis Miguel R. Sanchez229.Endemic (Nonvenereal) Treponematosis Miguel R. Sanchez230.Chancroid Stephan Lautenschlager and Alfred R. Eichmann231.Lymphogranuloma Venereum Richard Rothenberg232.Granuloma Inguinale Richard Rothenberg233.Gonorrhea David S. Feingold and Claire P. Mansur234.Other Venereal Diseases Alfred R. Eichmann and Stephan LautenschlagerSection 32Infestations235.Leishmaniasis and Other Protozoan Infections Sidney N. Klaus, Shoshana Frankenburg, and A. Damian Dhar236.Cysticercosis and Other Helminthic Infections Leslie C. Lucchina and Mary E. WilsonSection 33Bites and Stings237.Bites and Stings of Terrestrial and Aquatic Life Mark Jordan Scharf and Jennifer Susan Daly238.Scabies and Pediculosis Stephen P. Stone239.Arthropod Bites and Stings David C. Wilson, Michael L. Smith, and Lloyd E. King, Jr.PART SIXTherapeuticsSection 34Evidence-Based Dermatology240.Evidence-Based Dermatology Michael Bigby and Moyses SzkloSection 35Topical Therapy241.Pharmacokinetics and Topical Applications of Drugs Hans Schaefer, Thomas E. Redelmeier, and Gerhard J. Nohynek242.Principles of Topical Therapy Bruce E. Strober, Ken Washenik, and Jerome L. Shupack243.Topical Glucocorticoids Isabel C. Valencia and Francisco A. Kerdel244.Topical Retinoids Sewon Kang and John J. Voorhees245.Topical Antibiotics Mark W. Bonner, Paul M. Benson, and William D. James246.Topical Antifungal Agents James E. Fitzpatrick247.Sun Protective Agents: Formulations, Effects, and Side Effects Francis P. Gasparro, Douglas Brown, Brian L. Diffey, John S. Knowland, and Vivienne Reeve248.Keratolytic Agents Howard P. Baden and Lynn A. Baden249.Topical Cytotoxic Agents Lesley Clark-Loeser, Ken Washenik, and Jerome L. Shupack250.Topical Immunomodulators Robert Sidbury and Jon M. Hanifin251.Other Topical Medications Adam I. Rubin, Nicole LaNatra, and Matthew J. Stiller252.Cosmetics and Skin Care in Dermatologic Practice Patricia G. Engasser and Howard I. MaibachSection 36Systemic Therapy253.Systemic Glucocorticoids Victoria P. Werth254.Sulfones Stephen I. Katz255.Aminoquinolines Jeffrey R. LaDuca and Anthony A. Gaspari256.Cytotoxic and Antimetabolic Agents Christopher T. Cassetty, Jerome L. Shupack, and Ken Washenik257.The Retinoids Stephane Kuenzli and Jean-Hilaire Saurat258.Antihistamines Nicholas A. Soter259.Overview of Antibiotics Jan V. Hirschmann260.Antiviral Drugs Raphael Dolin261.Oral Antifungal Agents Nellie Konnikov and Helen Raynham262.Immunosuppressive and Immunomodulatory Drugs H. Carlos Nousari and Grant J. Anhalt263.Immunobiologicals in Dermatology James G. Krueger and Alice B. Gottlieb264.Thalidomide Gerhard Tappeiner and Klaus Wolff265.Therapeutic Photomedicine: Phototherapy Jean Krutmann and Akimichi Morita266.Photochemotherapy and Photodynamic Therapy Herbert Hoenigsmann, Rolf-Markus Szeimies, Robert Knobler, Thomas B. Fitzpatrick, Madhukar A. Pathak, and Klaus Wolff267.Lasers in Dermatology Graeme M. Lipper and R. Rox AndersonSection 37Surgery in Dermatology268.Dermatologic Surgery: Introduction and Approach June K. Robinson and George J. Hruza269.Skin Resurfacing: Chemical Peels Harold J. Brody270.Skin Resurfacing: Dermabrasion Christopher B. Harmon and John M. Yarborough, Jr.271.Skin Resurfacing: Laser George J. Hruza, Jeffrey S. Dover, and Kenneth A. Arndt272.Wound Dressings Michelle M. Choucair, Ysabel M. Bello, and Tania J. Philips273.Treatment of Varicose and Telangiectatic Veins Robert A. Weiss and Margaret A. Weiss274.Tumescent Liposuction Rhoda S. Narins, Arnold William Klein, and Jeffrey A. Klein275.Substances for Soft-Tissue Augmentation Arnold William Klein276.Botulinum Toxin Richard G. Glogau277.Hair Transplantation and Alopecia Reduction Walter Unger and Robert Unger278.Cryosurgery Gloria F. Graham, K. Andrew Cerveny, Jr., and James SanFilippo279.Mohs Micrographic Surgery Ken K. Lee and Neil A. Swanson280.Nail Surgery Robert BaranIndex

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