Animal models of human inflammatory skin diseases

著者

• Chan, Lawrence S.

書誌事項

Animal models of human inflammatory skin diseases

ed. by Lawrence S. Chan

CRC Press, 2003

注記

Includes bibliographical references and index

内容説明・目次

内容説明

Progress in understanding skin diseases has been aided enormously by the use of tissues derived from animals, by studying normal processes in animals, and by the development of animal models. The cellular activities in animals and humans are remarkably similar and the actual pathological process of an inflammatory skin disease can only be accurately observed and analyzed in a living animal model, and not in any in vitro model system. These factors have led to the regular use of animal tissues and models to allow the disease processes to be studied at a much greater depth. Animal Models of Human Inflammatory Skin Diseases features the principles and practices of how to go about studying inflammatory skin diseases using live animal models. On the principle side, the book describes the comparative structure and function of the skin, and the comparative immunology system in animal species commonly used as models. From the practical perspective, it presents a general discussion on methods of experimental animal modeling and contains specific expert experience on individual models. The authors include a detailed method of disease induction for each model, present chapters on comparative histology and immunology, and discuss potential targets of disease intervention. Written by biomedical investigators with first-hand experience in their chosen fields, this book is a valuable guide and reference for investigators in the biomedical and pharmaceutical sciences. It provides an instantaneous comparison between the skin structure and immunology of humans and animals, aiding in the interpretation and application of pathologic and immunologic findings.

目次

PART I. COMPARATIVE STRUCTURE AND FUNCTION OF THE SKIN Comparative Structure and Function of the Skin: Overview of Structures and Components Comparative Structure and Function of the Skin: Epithelial Basement Membrane Zone PART II. COMPARATIVE IMMUNOLOGY Human Immune System Canine Immune System Rat Immune System Mouse Immune System PART III. IMMUNE PRIVILEGE AND SKIN INFLAMMATION Immune Privilege of the Eye Theory of Immune Privilege of the Hair Follicle PART IV. METHODS OF EXPERIMENTAL ANIMAL MODELING Passive Transfer and Active Induction of Autoimmune Diseases Adoptive Transfer of Cellular Immunity Molecular Biological Manipulation of the Immune System by Transgenic Techniques PART V. INFLAMMATORY SKIN DISEASE MODELS Section A. Bullous Pemphigoid Natural Bullous Pemphigoid in Companion Animals Experimental Mouse Model of Bullous Pemphigoid: Passive Transfer of Anti-type XVII Collagen Antibodies Section B. Epidermolysis Bullosa Acquisita Spontaneous Canine Model of Epidermolysis Bullosa Acquisita Section C. Mucous Membrane Pemphigoid Spontaneous Canine Model of Mucous Membrane Pemphigoid Experimental Mouse Model of Mucous Membrane Pemphigoid: Passive Transfer of Anti-laminin 5 Antibodies Section D. Pemphigus Vulgaris Spontaneous Canine Model of Pemphigus Vulgaris Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Desmoglein-targeting Antibodies Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Nondesmoglein 1 & 3 Antibodies Section E. Pemphigus Foliaceus Spontaneous Canine Model of Pemphigus Foliaceus Experimental Mouse Model of Pemphigus Foliaceus: Passive Transfer of Desmoglein-targeting Antibodies Section F. Psoriasis Experimental Chimeric SCID Mouse/Human Skin Model of Psoriasis: Induction by Transfer of Cellular Immunity Experimental Mouse Model of Psoriasis by Transgenic Expression of Integrin Section G. Atopic Dermatitis Spontaneous Canine Model of Atopic Dermatitis Spontaneous Mouse Model of Atopic Dermatitis in the NC/Nga Mice Experimental Mouse Model of Atopic Dermatitis by Transgenic Expression of Cytokine Experimental Mouse Model of Atopic Dermatitis: Induction by Oral Allergen Experimental Mouse Model of Atopic Dermatitis: Induction by Epicutaneous Application of Allergen Section H. Alopecia Areata Spontaneous and Experimental Skin Graft Transfer Mouse Model of Alopecia Areata Spontaneous Rat Model of Alopecia Areata in the Dundee Experimental Bald Rat (DEBR) Spontaneous Canine Model of Alopecia Areata Experimental Chimeric SCID Mouse/Human Skin Model of Alopecia Areata: Induction by Transfer of Cellular Immunity Section I. Scleroderma Spontaneous Mouse Model of Scleroderma Experimental Mouse Model of Scleroderma/Graft vs. Host Disease: Induction by Transfer of Cellular Immunity Experimental Mouse Model of Scleroderma: Induction by Bleomycin

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詳細情報

• NII書誌ID(NCID): BA65176902
• ISBN:
  • 0849313910
• LCCN: 2003060292
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Boca Raton, FL
• ページ数/冊数: 564 p.
• 大きさ: 26 cm.
• 分類:
  • LCC : RL231
• 件名:
  • LCSH : Skin -- Inflammation -- Animal models
  • LCSH : Alopecia areata -- Animal models