Animal models of human inflammatory skin diseases
著者
書誌事項
Animal models of human inflammatory skin diseases
CRC Press, 2003
大学図書館所蔵 全4件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Progress in understanding skin diseases has been aided enormously by the use of tissues derived from animals, by studying normal processes in animals, and by the development of animal models. The cellular activities in animals and humans are remarkably similar and the actual pathological process of an inflammatory skin disease can only be accurately observed and analyzed in a living animal model, and not in any in vitro model system. These factors have led to the regular use of animal tissues and models to allow the disease processes to be studied at a much greater depth.
Animal Models of Human Inflammatory Skin Diseases features the principles and practices of how to go about studying inflammatory skin diseases using live animal models. On the principle side, the book describes the comparative structure and function of the skin, and the comparative immunology system in animal species commonly used as models. From the practical perspective, it presents a general discussion on methods of experimental animal modeling and contains specific expert experience on individual models. The authors include a detailed method of disease induction for each model, present chapters on comparative histology and immunology, and discuss potential targets of disease intervention.
Written by biomedical investigators with first-hand experience in their chosen fields, this book is a valuable guide and reference for investigators in the biomedical and pharmaceutical sciences.
It provides an instantaneous comparison between the skin structure and immunology of humans and animals, aiding in the interpretation and application of pathologic and immunologic findings.
目次
PART I. COMPARATIVE STRUCTURE AND FUNCTION OF THE SKIN
Comparative Structure and Function of the Skin: Overview of Structures and Components
Comparative Structure and Function of the Skin: Epithelial Basement Membrane Zone
PART II. COMPARATIVE IMMUNOLOGY
Human Immune System
Canine Immune System
Rat Immune System
Mouse Immune System
PART III. IMMUNE PRIVILEGE AND SKIN INFLAMMATION
Immune Privilege of the Eye
Theory of Immune Privilege of the Hair Follicle
PART IV. METHODS OF EXPERIMENTAL ANIMAL MODELING
Passive Transfer and Active Induction of Autoimmune Diseases
Adoptive Transfer of Cellular Immunity
Molecular Biological Manipulation of the Immune System by Transgenic Techniques
PART V. INFLAMMATORY SKIN DISEASE MODELS
Section A. Bullous Pemphigoid
Natural Bullous Pemphigoid in Companion Animals
Experimental Mouse Model of Bullous Pemphigoid: Passive Transfer of Anti-type XVII Collagen Antibodies
Section B. Epidermolysis Bullosa Acquisita
Spontaneous Canine Model of Epidermolysis Bullosa Acquisita
Section C. Mucous Membrane Pemphigoid
Spontaneous Canine Model of Mucous Membrane Pemphigoid
Experimental Mouse Model of Mucous Membrane Pemphigoid: Passive Transfer of Anti-laminin 5 Antibodies
Section D. Pemphigus Vulgaris
Spontaneous Canine Model of Pemphigus Vulgaris
Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Desmoglein-targeting Antibodies
Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Nondesmoglein 1 & 3 Antibodies
Section E. Pemphigus Foliaceus
Spontaneous Canine Model of Pemphigus Foliaceus
Experimental Mouse Model of Pemphigus Foliaceus: Passive Transfer of Desmoglein-targeting Antibodies
Section F. Psoriasis
Experimental Chimeric SCID Mouse/Human Skin Model of Psoriasis: Induction by Transfer of Cellular Immunity
Experimental Mouse Model of Psoriasis by Transgenic Expression of Integrin
Section G. Atopic Dermatitis
Spontaneous Canine Model of Atopic Dermatitis
Spontaneous Mouse Model of Atopic Dermatitis in the NC/Nga Mice
Experimental Mouse Model of Atopic Dermatitis by Transgenic Expression of Cytokine
Experimental Mouse Model of Atopic Dermatitis: Induction by Oral Allergen
Experimental Mouse Model of Atopic Dermatitis: Induction by Epicutaneous Application of Allergen
Section H. Alopecia Areata
Spontaneous and Experimental Skin Graft Transfer Mouse Model of Alopecia Areata
Spontaneous Rat Model of Alopecia Areata in the Dundee Experimental Bald Rat (DEBR)
Spontaneous Canine Model of Alopecia Areata
Experimental Chimeric SCID Mouse/Human Skin Model of Alopecia Areata: Induction by Transfer of Cellular Immunity
Section I. Scleroderma
Spontaneous Mouse Model of Scleroderma
Experimental Mouse Model of Scleroderma/Graft vs. Host Disease: Induction by Transfer of Cellular Immunity
Experimental Mouse Model of Scleroderma: Induction by Bleomycin
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