GTPases regulating membrane targeting and fusion

Author(s)

• Balch, William Edward
• Der, Channing J.
• Hall, A. (Alan)

Bibliographic Information

GTPases regulating membrane targeting and fusion

edited by William E. Balch, Channing J. Der, Alan Hall

（Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 403）

Elsevier Academic Press, c2005

Note

Includes bibliographical references and indexes

Description and Table of Contents

Description

Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of Methods in Enzymology, GTPases Regulating Membrane Targeting and Fusion, provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation.

by "Nielsen BookData"

Details

• NCID: BA74786686
• ISBN:
  • 0121828085
• Country Code: ne
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Amsterdam ; San Diego, Calif. ; Tokyo
• Pages/Volumes: xliii, 863 p., [28] p. of plates
• Size: 24 cm
• Subject Headings:
  • MESH : Enzymes
  • MESH : Membrane Fusion
• Parent Bibliography ID:
  • BA00197543