The comprehensive sourcebook of bacterial protein toxins

著者

• Alouf, J. E. (Joseph E.)
• Popoff Michel R.

書誌事項

The comprehensive sourcebook of bacterial protein toxins

editors, Joseph E. Alouf and Michel R. Popoff

Elsevier/Academic Press, c2006

3rd ed

注記

Includes bibliographies and index

内容説明・目次

内容説明

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.

目次

Introduction A 116-year story of bacterial protein toxins (1888-2004): From 'diphtheritic poison' to molecular toxinology Evolutionary aspects of toxin-producing bacteria Mobile genetic elements and pathogenicity islands encoding bacterial toxins Regulation systems of toxin expression Toxin secretion systems Intracellular trafficking of bacterial protein toxins Translocation of bacterial protein toxin into the cytosol Bacterial toxins and virulence factors targeting the actin cytoskeleton and intracellular junctions Bacterial toxins and mitochondria Toxins activating RHO GTPases and exploiting the cellular ubiquitin/proteasome machineries Toxin receptors Molecular, functional and evolutionary aspects of ADP-ribosylating toxins Diphtheria toxin Attack of the nervous system by clostridial toxins: Physical findings, cellular and molecular actions Uptake and transport of clostridial neurotoxins Bacillus anthracis toxins Large clostridial cytotoxins modifying small GTPases Bordetella protein toxins Vibrio Cholerae and Escherichia Coli thermolabile enterotoxin The Shiga toxins: Properties and action on cells Helicobacter pylori vacuolating toxin Pasteurella multocida toxin Cytolethal distending toxins Pseudomonas aeruginosa toxins Escherichia coli heat- stable enterotoxin b Paradigms and classification of bacterial membrane -damaging toxins Membrane damaging and cytotoxic phospholipases Bacteroides fragilis toxins Structure and mode of action of RTX cytolysins Genetics and phylogeny of RTX cytolysins The family of two-component cytolysins of Serratia and other bacteria Alpha-helix and Beta-barrel pore-forming toxins (leucocidins, alpha-, gamma- and delta-cytolysins) of Staphylococcus aureus Aerolysin and related Aeromonas toxins Clostridium septicum pore-forming alpha-toxin Clostridium perfringens epsilon toxin Repertoire and general features of the family of cholesterol-dependent cytolysins Comparative three-dimensional structure of cholesterol-dependent cytolysins Perfringolysin O and Intermedilysin: mechanisms of pore formation by the cholesterol-dependent cytolysins Pneumolysin: structure, function and role in disease Listeriolysin Enterococcus faecalis cytolysin toxin Streptolysin S: one of the most potent and elusive of all bacterial toxins The group B streptococcal beta-haemolysin/cytolysin Haemolysins of Vibrio cholerae and other Vibrio species Clostridium perfringens enterotoxin Bacillus cereus enterotoxins, bi- and tri-component cytolysins and other haemolysins Uropathogenic Escherichia coli cytolysins Escherichia coli, Vibrio and Yersinia species heat-stable enterotoxins What are superantigens ? Staphylococcal superantigens and the diseases they cause Streptococcal superantigenic toxins Superantigenic toxin of Yersinia pseudotuberculosis Comparative three-dimensional structure of bacterial superantigenic toxins Induction and modulation of inflammatory networks by bacterial protein toxins Clostridial toxins in the pathogenesis of gas gangrene Staphylococcal exfoliative toxins Medical applications of botulinum neurotoxins Bacterial protein toxins as food poisons Engineering of bacterial toxins for research and medicine Engineered bacterial toxin vaccines and adjuvants Toxins as tools Bacterial protein toxins as biological weapons INDEX

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詳細情報

• NII書誌ID(NCID): BA75166927
• ISBN:
  • 0120884453
• 出版国コード: ne
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Amsterdam ; Tokyo
• ページ数/冊数: xxiii, 1047 p.
• 大きさ: 29 cm