Eukaryotic transcription factors
著者
書誌事項
Eukaryotic transcription factors
Elsevier Academic Press, 2004
4th ed
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality.
目次
DNA sequences, transcription factors and chromatin structureThe importance of transcriptionChromatin structure and its remodelling Chromatin structure and gene regulationChromatin remodelling factorsHistone acetylationDNA sequence elementsThe gene promoterSequences involved in the basic process of transcription Sequences involved in regulated transcriptionSequences which act at a distanceNegatively acting DNA sequencesInteraction between factors bound at various sitesConclusionsReferencesMethods for studying transcription factorsIntroductionMethods for studying DNA-protein interactionsDNA mobility shift assayDNaseI footprinting assayMethylation interference assayIn vivo Footprinting assayMethods for purifying and/or cloning transcription factorsProtein purificationGene cloningUse of cloned genesDomain mapping of transcription factorsDetermining the DNA binding specificity of an uncharacterised factorIdentification of target genes for transcription factors
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