Conditional mutagenesis : an approach to disease models
Author(s)
Bibliographic Information
Conditional mutagenesis : an approach to disease models
(Handbook of experimental pharmacology, v. 178)
Springer, c2007
Available at 20 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
In this book, leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse and their application to model human physiology and pathophysiology. The book illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. In addition, it considers the development of new drugs to treat human diseases.
Table of Contents
Part 1: Tools for Conditional Mutagenesis.- Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinases. Cre/loxP-mediated Chromosome Engineering of the Mouse Genome. Tetracycline-Controlled Genetic Switches Novel Gene Switches. Improved Embryonic Stem Cell Technologies . Gene Trap Mutagenesis. RNA Interference in Mice. Viral Vectors: A Wide Range of Choices and High Levels of Service. Conditional mutagenesis by cell permeable proteins: Potential, Limitations and Prospects.- Part 2: Examples of Conditional Disease Models.- Analysis of Mouse Development with Conditional Mutagenesis. Conditional Mouse Models of Cancer. Conditional Mutagenesis Reveal Immunological Functions of Widely Expressed Genes: Activation Thresholds, Homeostatic Mechanisms and Disease Models . Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and Memory. A Novel Conditional Knockout Strategy Applied to Serotonin Receptors. Conditional Mouse Models for Friedreich Ataxia, A Neurodegenerative Disorders Associating Cardiomyopathy. Animal Models in Cardiovascular Diseases: New Insights from Conditional Models. Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders. Conditional Mouse Models to Study Developmental and Pathological Gene Function in Muscle. Analysis of Calcium Channels by Conditional Mutagenesis. Conditional Mutagenesis of G-protein Coupled Receptors and G-proteins. Contribution of Targeted Conditional Somatic Mutagenesis to Deciphering Retinoid X receptor (RXR) Functions and to Generating Mouse Models of Human Diseases
by "Nielsen BookData"