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Clinical applications ISBN 9780123736017
Description
Although it is one of the most-widely studied viruses, many mysteries still remain about HIV. Covering the latest advances and challenges associated with clinical application of new antiviral drugs and vaccines, this revised edition is a companion to Murad: HIV-1: Molecular Biology and Pathogenesis, Second Edition. Leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus.
Table of Contents
HIV Therapeutics: Past, Present, and Future
HIV Drug Resistance and Viral Fitness
Inhibitors of HIV-1 Reverse Transcriptase
HIV-I Protease: Maturation, Enzyme Specificity, and Drug Resistance
HIV-I Integrase Inhibitors: Past, Present, and Future
Selection of HIV Replication Inhibitors: Chemistry and Biology
Maturation or assembly inhibitor compounds against HIV-1
HIV-I Gene Therapy: Promise for the Future
Assessment of HIV Vaccine Development: Past, Present, and Future
CTL immunity approaches for HIV-1 vaccines
humoral immunity approaches for HIV-1 vaccines.
HIV-I-Associated Central Nervous System Dysfunction
Molecular Mechanisms of Human Immunodeficiency Virus Type I Mother-Infact Transmission
Molecular Epidemiology of HIV-I: An Example of Asia
Simian Immunodeficiency Virus Infection of Monkeys as a Model System for the Study of AIDS Pathogenesis, Treatment and Prevention
Animal Models for AIDS Pathogenesis
SCID-hu mouse models for studying HIV-AIDS and for drug testing.
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Viral mechanisms ISBN 9780123736109
Description
This volume covers the latest advances in the mechanisms of pathogenesis of the HIV-1 virus on target cells. Its companion volume, Advances in Pharmacology 56, shows how new developments in understanding the virus translate to the clinical setting.
Table of Contents
HIV-1 RNA PackagingStructure and Function of the HIV Envelope Glycoprotein as Entry Mediator, Vaccine Immunogen, and Target for InhibitorsHIV-1 Reverse Transcription: Close Encounters Between the Viral Genome and a Cellular tRNATranscription of HIV: Tat and Cellular ChromatinPosttranscriptional Control of HIV-1 and Other Retroviruses and Its Practical ApplicationsHIV Accessory Genes Vif and VpuInteractions of HIV-1 Viral Protein R with Host Cell ProteinsHIV-1 Protease: Structure, Dynamics, and InhibitionProperties, Functions, and Drug Targeting of the Multifunctional Nucleocapsid Protein of the Human Immunodeficiency VirusHuman Immunodeficiency Virus Type 1 Assembly, Release, and MaturationRole of Nef in HIV-1 Replication and PathogenesisTreatment Implications of the Latent Reservoir for HIV-1RNA Interference and HIV-1
by "Nielsen BookData"