Natural compounds as drugs
Author(s)
Bibliographic Information
Natural compounds as drugs
（Progress in drug research / edited by Ernest Jucker, vol. 65-66）
Birkhauser, 2008
- v. 1
- v. 2
Available at / 8 libraries
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v. 1499.39/P442/80109646280109648
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Note
Includes bibliographical references and index
Description and Table of Contents
- Volume
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v. 1 ISBN 9783764380984
Description
In a real tour de force of pharmacological literature, this edited volume's chapters highlight the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such complex chemical information, what makes them unique, as they often are, and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
Table of Contents
Mother Nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery.- Drug discovery and development with plant-derived compounds.- Evolutionary mechanisms underlying secondary metabolite diversity.- Biodiversity, chemical diversity and drug discovery.- High impact technologies for natural products screening.- Virtual screening for the discovery of bioactive natural products.- Strain improvement for production of pharmaceuticals and other microbial metabolites by fermentation.- Nutritional and engineering aspects of microbial process development.- Natural products from plant cell cultures.
- Volume
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v. 2 ISBN 9783764385941
Description
The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. A compilation of current applicable technology makes this a brilliant reference work.
Table of Contents
Activation of fungal silent gene clusters: A new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.- Cheminformatics analysis of natural products: Lessons from nature inspiring the design of new drugs.- Chemical-genetic approaches for exploring the mode of action of natural products.- Epothilones as lead structures for new anticancer drugs - pharmacology, fermentation, and structure-activity-relationships.- Histone deacetylase inhibitors from microorganisms: the Astellas experience.- Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.- Artemisinin - an innovative cornerstone for anti-malaria therapy.
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