Angiogenesis : in vitro systems
著者
書誌事項
Angiogenesis : in vitro systems
（Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 443）
Academic Press, c2008
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注記
Includes bibliographical references and indexes
内容説明・目次
内容説明
Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over antiogenesis. Diseases that are angiogensis-dependent result when blood vessels either grow excessively or insufficiently.
目次
- Studying cell signaling pathways
- Flow mediated signaling
- Endothelial cell adhesion and migration on the ECM
- EC sprouting assays
- Lumen formation assays
- Isolation and propagation of EC's or SMC's
- Cell-based assays to screen anti-angiogenic agents (chemical approach
- ES cell models of vascular network formation
- Co-culture studies with EC plus other cell types
- Aortic ring sprouting (multiple cell types present)
- Effects of hypoxia or hyperoxia
- Vascular Proteomics
- In vitro vascular barrier function
- EC leukocyte interactions
- ECM signaling to the vasculature
- Vascular Integrin signaling
- Mechanical Signaling in blood vessels
- Vascular and neuronal patterning
- Vascular growth factors and their signals
- VEGF receptor signal transduction
- Development and testing of monoclonal antibodies directed to angiogenic targets.
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