Protein interaction networks : computational analysis

著者

    • Zhang, Aidong

書誌事項

Protein interaction networks : computational analysis

Aidong Zhang

Cambridge University Press, c2009

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内容説明・目次

内容説明

The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Proteins seldom act as single isolated species; rather, proteins involved in the same cellular processes often interact with each other. Functions of uncharacterized proteins can be predicted through comparison with the interactions of similar known proteins. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.

目次

  • 1. Introduction
  • 2. Experimental approaches to generation of protein-protein interaction data
  • 3. Computational methods for the prediction of protein-protein interactions
  • 4. Basic properties and measurements of protein interaction networks
  • 5. Modularity analysis of protein interaction networks
  • 6. Topological analysis of protein interaction networks Woo-chang Hwang
  • 7. Distance-based modularity analysis
  • 8. Graph-theoretic approaches to modularity analysis
  • 9. Flow-based analysis of protein interaction networks
  • 10. Statistics and machine learning based analysis of protein interaction networks Pritam Chanda and Lei Shi
  • 11. Integration of gene ontology into the analysis of protein interaction networks Young-rae Cho
  • 12. Data fusion in the analysis of protein interaction networks
  • 13. Conclusion.

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