Abridged thermodynamic and thermochemical tables: with charts British Units
著者
書誌事項
Abridged thermodynamic and thermochemical tables: with charts British Units
（The commonwealth and international library of science, technology, engineering and liberal studies, Thermodynamics and fluid mechanics division for mechanical engineers）
Pergamon Press, 1968
[1st ed.]
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注記
7 folded charts in pocket
内容説明・目次
内容説明
From Globular Proteins to Amyloids proposes a model and mechanism for explaining protein misfolding. Concepts presented are based on a model originally intended to show how proteins attain their native conformations. This model is quantitative in nature and founded upon arguments derived from information theory. It facilitates prediction and simulation of the amyloid fibrillation process, also identifying the progressive changes that occur in native proteins that lead to the emergence of amyloid aggregations.
目次
1. Description of the fuzzy oil drop model 2. Folding with the active participation of water 3. Information coded in protein structure 4. Gobular or ribbon-like micelle 5. Proteins structured as spherical micelles 6. Local discordance 6. A. The active site in a single-chain enzyme identified as local deficiency of hydrophobicity 6. B. Protein-protein interaction encoded as an exposure of hydrophobic residues on the surface 6. C. Ligand binding cavity coded in form of local deficiency of hydrophobicity 7. Solenoid - amyloid under control 8. Composite structures 9. Permanent chaperons 9. A. Non-amyloid structure of the ass(1-42) polypeptide requiring a permanent chaperone 9. B. Structural properties of ass(1-42) chain fragments in complex with proteins acting as permanent chaperones 10. Amyloids 10. A. Amyloid as a ribbon-like micelle 10. B. Alternative conformations of the ass(1-40) amyloid protein 10. C. Specificity of amino acid sequence and its role in secondary and super secondary structure generation 11. Anti-amyloid drug design 12. Predicted structure of the transthyretin amyloid
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