G protein-coupled receptors in health and disease
著者
書誌事項
G protein-coupled receptors in health and disease
（Progress in molecular biology and translational science, v. 88-89）
Academic Press, c2009
- pt. A
- pt. B
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
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pt. B ISBN 9780123747563
内容説明
G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.
目次
1. Diseased G protein-coupled receptors: An Introduction
Ya-Xiong Tao
2. GPR56 and its related diseases
Xianhua Piao and Ze Tian
3. GnRHR mutations and hypogonadotropic hypogonadism
Nicholas de Roux
4. LHR mutations and reproductive disorders
Deborah L. Segaloff
5. FSHR mutations and reproductive disorders
Ya-Xiong Tao and Deborah L. Segaloff
6. V2R mutations and nephrogenic diabetes insipidus
Daniel G. Bichet
7. Calcium-sensing receptor mutations
Geoffrey N. Hendy
8. Diseases caused by prostacyclin receptor mutations
John Hwa and Kathleen A Martin
- 巻冊次
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pt. A ISBN 9780123747570
内容説明
G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.
目次
1. Rhodopsin-Mediated Retinitis PigmentosaKatherine M. Malanson and Janis Lem2. Human Diseases Associated with GPR54 MutationsMilena Gurgel Teles, Leticia Ferreira Gontijo Silveira, Suzy Bianco and Ana Claudia Latronico3. Diseases Associated with Growth Hormone-releasing hormone Receptor (GHRHR) MutationsMarco Martari and Roberto Salvatori4. The Melanocortin-1 Receptor Gene Polymorphism and Association with Human Skin CancerKimberley A. Beaumont, Yan Yan Liu and Richard A. Sturm5. The Molecular Basis of Adrenocorticotrophin Resistance Syndrome Lucila L K Elias and Adrian J L Clark6. Mutations in melanocortin-4 receptor and human obesityYa-Xiong Tao
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