Constitutive activity in receptors and other proteins

Author(s)

• Conn, P. Michael

Bibliographic Information

Constitutive activity in receptors and other proteins

edited by P. Michael Conn

（Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 484-485）

Academic Press, 2010

• pt. A
• pt. B

Note

Includes bibliographical references and indexes

Description and Table of Contents

Volume

pt. B ISBN 9780123812964

Description

This volume of Methods in Enzymology covers the current methodology for the detection and assessment of constitutively active proteins. The chapters written by expert authors who are leaders in the field, provide hints and tricks not available in primary research publications.It is extensively referenced, with useful figures and tables throughout the volume.

Table of Contents

Identification and characterization of Steroidogenic Factor-1 inverse agonists. Mabrouka Doghman, Franck Madoux, Peter Hodder, and Enzo Lalli Assessment of inverse agonism for the angiotensin II type 1 receptor Hiroshi Akazawa, Noritaka Yasuda, Shin-ichiro Miura, Issei Komuro Measurement of inverse agonism in BARs Carlos Alberto Taira Inverse agonism of antidepressants: in vitro and in vivo studies Joel Bockaert Differential inverse agonism at the human muscarinic M3 receptor Paola Casarosa Ghrelin Receptor: High Constitutive Activity and Methods for Developing Inverse Agonists. Constance Chollet Constitutive activity and inverse agonism at the a1a and a1b adrenergic receptor subtypes. Susanna. Cotecchia Measurement of inverse agonism of the cannabinoid receptor Tung Fong Constitutively Active Thyrotropin (TSH) and Thyrotropin-Releasing Hormone (TRH) Receptors and Their Inverse Agonists Marvin C. Gershengorn Inverse retinoid agonists and neutral antagonists Hinrich Gronemeyer ?-Aminobutyric Acid Type A (GABAA) Receptor Subtype Inverse Agonists as Therapeutic Agents in Cognition Gabriella Guerrini and Ciciani Giovanna Assays for inverse agonists in the visual system. Masahiro Kono Receptor-driven identification of novel human A3 adenosine receptor antagonists as potential therapeutic agents Silvia Paoletta, Stephanie Federico, Giampiero Spalluto and Stefano Moro Inverse agonists of steroidogenic factor SF-1 Fabrice Piu and Andria L. Del Tredici Methods to Measure G Protein Coupled Receptor Activity for the Identification of Inverse Agonists Gabriel Barreda-Gomez, M.Teresa Giralt and Rafael Rodriguez-Puertas Section II-- Novel Strategies and Techniques for Constitutive Activity and Inverse Agonism Use of Pharmacoperones to Reveal GPCR Structural Components Associated with Receptor Activation and Trafficking Jo Ann Janovick and P. Michael Conn Application of large-scale transiently transfected cells to functional assays of ion channels and other proteins. Jun Chen, Sujatha Gopalakrishnan, Marc R Lake, and Bruce R Bianchi Quantification of RNA Editing of the Serotonin 2C Receptor (5-HT2CR) Ex Vivo Maria Fe Lanfranco, Noelle C. Anastasio, Patricia K. Seitz, and Kathryn A. Cunningham Strategies for isolating constitutively-active and dominant-negative pheromone receptor mutants in yeast. Mercedes Dosil and James B. Konopka Development of a GPR23 Cell-based ss-Lactamase Reporter Assay Paul H. Lee and Bonnie J. Hanson Computational Modeling of Constitutively Active Mutants of GPCRs: C5a Receptor. Gregory V. Nikiforovich and Thomas J. Baranski TSH receptor monoclonal antibodies with agonist, antagonist and inverse agonist activities Jane Sanders, Ricardo Nunez Miguel, Jadwiga Furmaniak, Bernard Rees Smith Current standards, variations and pitfalls for the determination of constitutive TSHR activity in vitro Sandra Mueller, Holger Jaeschke, Ralf Paschke Towards the Rational Design of Constitutively Active KCa3.1 Mutant Channels Line Garneau, Helene Klein, Lucie Parent, Remy Sauve Fusion proteins as model systems for the analysis of constitutive GPCR activity Erich H. Schneider, Roland Seifert Screening for Novel Constitutively Active CXCR2 Mutants and Their Cellular Effects Giljun Park, Tom Masi, Chang K. Choi, Heejung Kim, Jeffrey M. Becker, and Tim E. Sparer A method for parallel solid-phase synthesis of iodinated analogues of the cannabinoid receptor type I (CB1) inverse agonist rimonabant Alan C. Spivey and Chih-Chung Tseng Coexpression systems as models for the analysis of constitutive GPCR activity Roland Seifert and Erich H. Schneider Modelling and simulation of inverse agonism dynamics Lloyd J. Bridge Design and Use of Constitutively Active STAT5 Constructs Michael A. Farrar In vitro and in vivo assays of protein kinase CK2 activity Renaud Prudent, Celine F. Sautel, Virginie Moucadel, Beatrice Laudet, Odilhe Filhol, and Claude Cochet

Volume

pt. A ISBN 9780123812988

Description

This volume of Methods in Enzymology covers the current methodology for the detection and assessment of constitutively active proteins. The chapters written by expert authors who are leaders in the field, provide hints and tricks not available in primary research publications.It is extensively referenced, with useful figures and tables throughout the volume.

Table of Contents

Section I-- Identification and Measurement of Constitutive Activity Constitutive activity at the cannabinoid CB1 receptor and behavioral responses Katherine E. Hanlon and Todd W. Vanderah Detecting constitutive activity and protean agonism at the cannabinoid-2 receptor. Massimiliano Beltramo, Rossella Brusa, Isabella Mancini, Paola Scandroglio, Massimiliano. Beltramo Modulation of constitutive activity of the ghrelin receptor by use of pharmacological tools as well as mutagenesis Birgitte Holst and Jacek Mokrosinski Assessment of constitutive activity and internalization of GPR54 (Kiss1-r). Macarena Pampillo and Andy Videsh Babwah Assessment of Constitutive Activity in EP Prostanoid Receptors Hiromichi Fujino, Toshihiko Murayama, and John W. Regan a1D-Adrenergic receptors: constitutive activity and reduced expression at the plasma membrane J Adolfo Garcia-Sainz, M. Teresa Romero-Avila and Luz del Carmen Medina Constitutive activity of the histamine H1 receptor Saskia Nijmeijer, Rob Leurs and Henry F Vischer Constitutive activity of somatostatin receptor subtypes Anat Ben-Shlomo, Kolja Wawrowsky and Shlomo Melmed Assessment of homologous internalization of constitutively active N111G mutant of AT1 receptor Mohiuddin Ahmed Bhuiyan and Takafumi Nagatomo Methods to detect cell surface expression and constitutive activity of GPR6 Balakrishna M. Prasad, Bettye Hollins and Nevin A. Lambert ss3-adrenoceptor agonists and (antagonists as) inverse agonists: history, perspective, constitutive activity and stereospecific binding. Maria Grazia Perrone and Antonio Scilimati Constitutive Activity of the Lutropin Receptor and its Allosteric Modulation by Receptor Heterodimerization Deborah L. Segaloff Assessing Constitutive Activity of Extracellular Calcium-Sensing Receptors in Vitro and in Bone Wenhan Chang, Melita Dvorak, and Dolores Shoback Constitutive Activity of Neural Melanocortin Receptors. Ya-Xiong Tao, Hui Huang, Zhi-Qiang Wang, Fan Yang, Jessica N. Williams, and Gregory V. Nikiforovich Measurement of Constitutive Activity of BMP Type I receptors Peter ten Dijke Probing the CA among dopamine D1 and D5 receptors and their mutants Bianca Plouffe, Jean-Philippe D'Aoust, Vincent Laquerre, Binhui Liang and Mario Tiberi Identification of Gain-of-Function Variants of the Human Prolactin Receptor Vincent Goffin, Roman L. Bogorad, and Philippe Touraine Investigations of Activated ACVR1/ALK2, a Bone Morphogenetic Protein (BMP) Type I Receptor that Causes Fibrodysplasia Ossificans Progressiva Frederick. Kaplan, Petra Seemann, Julia Haupt, Meiqi Xu, Vitali Lounev, Mary Mullins, Eileen M. Shore Identification and evaluation of constitutively active thyroid stimulating hormone receptor mutations Joaquin Lado-Abeal, Leah R. Quisenberry, and Isabel Castro-Piedras Assessment of constitutive activity of a G protein-coupled receptor, Cpr2, in Cryptococcus neoformans by heterologous and homologous methods Chaoyang Xue, Yina Wang, and Yen-Ping Hsueh In vitro and in vivo assessment of mu opioid receptor constitutive activity. Edward J. Bilsky, Denise Giuvelis, Melissa D. Osborn, Christina M. Dersch, Heng Xu and Richard B. Rothman Constitutively active -opioid methods Mark. Connor and John Traynor Protein Kinase Ck2 is a Constitutively-Active Enzyme That Promotes Cell Survival: Strategies To Identify Ck2 Substrates and Manipulate Its Activity In Mammalian Cells Jacob P. Turowec, James S. Duncan, Ashley C. French, Laszlo Gyenis, Nicole A. St. Denis, Greg J. Vilk, and David W. Litchfield Assessment of Ck2 Constitutive Activity In Cancer Cells Maria Ruzzene, Giovanni Di Maira, Kendra Tosoni, and Lorenzo A. Pinna Structural basis of the constitutive activity of protein kinase CK2 Birgitte B. Olsen, Barbara Guerra, Karsten Niefind and Olar-Georg Issinger font error Measuring the Constitutive Activation of c-Jun N-terminal Kinase Isoforms Ryan T. Nitta, Shawn S. Badal, and Albert J. Wong Measurement of constitutive MAPK and PI3K/AKT signaling activity in human cancer cell lines. Keiran S.M. Smalley Constitutive activity of GPR40/FFA1: Intrinsic or assay dependent? Leigh A Stoddart and Graeme Milligan Constitutive activity of TRP channels: methods for measuring the activity and its outcome Baruch Minke Measurement of Orexin (Hypocretin) and Substance P Effects On Constitutively Active Inward Rectifier K+ Channels in Brain Neurons Yasuko Nakajima and Shigehiro Nakajima Characterization of G protein receptor kinase 4 and measuring its constitutive activity in vivo Bradley T. Andresen Voltage-clamp based methods for the detection of constitutively active acetylcholine-gated IK,ACh channels in the diseased heart Niels Voigt, Samy Makary, Stanley Nattel, Dobromir Dobrev Assaying Wave and WASH complex constitutive activities towards the Arp2/3 complex. Emmanuel DERIVERY and Alexis GAUTREAU

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Details

• NCID: BB03931636
• ISBN:
  • 9780123812988
  • 9780123812964
• Country Code: ne
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Amsterdam ; Tokyo
• Pages/Volumes: 2 v.
• Size: 24 cm
• Classification:
  • DC22 : 572.696
• Subject Headings:
  • LCSH : Proteins
• Parent Bibliography ID:
  • BA00197543