Handbook of the biology of aging
著者
書誌事項
Handbook of the biology of aging
（The handbooks of aging / editor-in chief, James E. Birren）
Academic, 2011
7th ed
- : pbk
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内容説明・目次
内容説明
Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings and discoveries in the field. This volume is part of The Handbooks of Aging series, which also includes The Handbook of the Psychology of Aging and The Handbook of Aging and the Social Sciences. The book is organized into two parts. Part 1 covers basic aging processes. It covers concepts relevant to clinical research, such as muscle, adipose tissue, and stem cells. It discusses research on how dietary restriction can slow down the aging process and extend life in a wide range of species. Part 2 deals with the medical physiology of aging. It contains several chapters on the aging of the human brain. These chapters deal not only with diseases but also with normal aging changes to cerebral vasculature and myelination as well as the clinical implications of those changes. Additional chapters cover how aging affects central features of human health such as insulin secretion, pulmonary and cardiac function, and the ability to maintain body weight and body temperature. The volume is primarily directed at basic researchers who wish to keep abreast of new research outside their own subdiscipline. It will also be useful to medical, behavioral, and social gerontologists who want to learn about the discoveries of basic scientists and clinicians.
目次
Part I: Basic Aging Processes
1. The Genetic Network of Lifespan Extension by Dietary Restriction - Eric Greer and Anne Brunet
2. Role of the Somatotropic Axis in Mammalian Aging - Holly M.Brown-Borg
3. Mechanisms of Mitochondrial Free Radical Production and their Relationship to the Aging Process - Casey L. Quinlan, Jason R. Treberg, and Martin D. Brand
4. Aging and Apoptosis in Muscle - Stephen E. Alway, Michael R. Morissette, and Parco M. Siu
5. Aging and Adipose Tissue - Roberta Florido, Tamara Tchkonia, and James L. Kirkland
6. Aging of Stem Cells: Intrinsic Changes and Environmental Influences - Ling Liu and Thomas A. Rando
7. Leukocyte Telomere Dynamics, Human Aging and Lifespan - Abraham Aviv
8. An Unbiased Appraisal of the Free Radical Theory of Aging - Michael Lustgarten, Florian L. Muller, and Holly Van Remmen
9. TOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species - Pankaj Kapahi and Lutz Kockel
10. Comparative Genetics of Aging - George L. Sutphin and Matt Kaeberlein
11. Sirtuins in Aging and Age-Related Diseases - Marcia C. Haigis and David A. Sinclair
12. Inflammation in Aging Processes: An Integrative and Ecological Perspective - Caleb E. Finch
13. Protein Homeostasis and Aging - Susmita Kaushik and Ana Maria Cuervo
Part II: Medical Physiology of Aging
14. Terminal Weight Loss, Frailty, and Mortality - Edward J. Masoro
15. Human Brain Myelination Trajectories Across the Lifespan: Implications for CNS Function and Dysfunction - Jonathan E. Sherin and George Bartzokis
16. Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Interventions - Farzaneh A. Sorond and Lewis A. Lipsitz
17. Aging and Insulin Secretion - Jeffrey B. Halter
18. Cardiovascular Effects of Aging in Primates - Gender Differences - Hongyu Qiu, Christophe Depre, Dorothy E. Vatner, and Stephen F. Vatner
19. Cerebral Vascular Dysfunction with Aging - Frank M. Faraci
20. Pulmonary Function in Aging Humans - Nigel A.S. Taylor
21. Calorie Restriction in Nonhuman and Human Primates - Luigi Fontana, Ricki J. Colman, John O. Holloszy, and Richard Weindruch
22. Age-related Changes in Thermoreception and Thermoregulation - Eus J.W. Van Someren
23. Sex Differences in Longevity and Aging - Steven N. Austad
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