Proteases and the regulation of biological processes
著者
書誌事項
Proteases and the regulation of biological processes
（Biochemical Society Symposia, no. 70）
Portland Press, c2003
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This title is the published proceedings of the Biochemical Society meeting held at Imperial College London in December 2002. The meeting brought together international leaders in the field to discuss contemporary advances in protease research and was dedicated to Dr Alan J Barrett to honour his research achievements and contributions to the field of proteolytic enzymes on his 65th birthday. This book aims to provide an overview of contemporary research on the roles of proteolytic enzymes in biological systems. Contributions come from some of the leading scientists in this field and cover areas such as the proteasome and antigen presentation; extracellular and pericellular proteolysis; inflammation and tissue destruction; protease inhibitors and potential for therapy; intracellular proteolysis and apoptosis; and proteolysis and cell migration.
目次
- Structural basis of matrix metalloproteinase function
- papain-like lysosomal cysteine proteases and their inhibitors - drug discovery targets?
- roles for asparagine endopeptidase in class II MHC-restricted antigen processing
- substrate specificity and inducibility of TACE revisited - Ala-Val preference and induced intrinsic activity
- meprin proteolytic complexes at the cell surface and in extracellular spaces
- roles of TIMPs in pericellular proteolysis - the specificity is in the detail
- collagen-platelet interactions - recognition and signalling
- control of the expression of inflammatory response genes
- use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity
- proteolysis of the collagen fibril in osteoarthritis
- cytokine synergy, collagenases and cartilage collagen breakdown
- proteolytic "defences" and the accumulation of oxidized polypeptides in cataractogenesis and atherogenesis
- proteases as drug targets
- how serpins change their shape for better and for worse
- cystatins
- designing TIMP variants that are selective metalloproteinase inhibitors
- memapsin 2, a drug target for Alzheimer's disease
- control of lipid metabolism by regulated intramembrane proteolysis of SREBPs
- caspase activation
- separase regulation during mitosis
- membrane-type 1 matrix metalloproteinase and cell migration
- cathepsin B and its role(s) in cancer progression
- proteolytic and non-proteolytic migration of tumour cells and leucocytes.
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