Introduction to proteins : structure, function, and motion
著者
書誌事項
Introduction to proteins : structure, function, and motion
（Chapman and Hall/CRC mathematical & computational biology series / series editors Alison M. Etheridge ... [et al.]）
CRC Press, c2011
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life.
With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural-biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules.
The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure-function relationship of proteins by presenting the principles of protein action in the form of guidelines.
This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.
目次
Introduction
THE IMPORTANCE OF PROTEINS IN LIVING ORGANISMS
STRUCTURAL COMPLEXITY AND ITS EFFECT ON PROTEIN FUNCTION
NON-COVALENT INTERACTIONS BETWEEN ATOMS IN BIOMOLECULES
Protein Structure
INTRODUCTION
PRIMARY STRUCTURE
SECONDARY STRUCTURE
TERTIARY STRUCTURE
QUATERNARY STRUCTURE
POST-TRANSLATIONAL MODIFICATIONS
Methods of Structure Determination and Prediction
INTRODUCTION
DIFFRACTION/SCATTERING METHODS
SPECTROSCOPIC METHODS
COMPUTATIONAL METHODS FOR STRUCTURE PREDICTION
CONCLUSIONS
THE PROTEIN DATA BANK (PDB)
Energetics and Protein Stability
BASIC PRINCIPLES OF THERMODYNAMICS
PROTEIN STABILITY AND THE FORCES INVOLVED
PROTEIN DENATURATION AND ADAPTATION TO EXTREME CONDITIONS
STABILITY ENHANCEMENT OF INDUSTRIAL ENZYMES USING PROTEIN ENGINEERING
Protein Structural Dynamics
INTRODUCTION
PROTEIN FOLDING
FOLDED STATE DYNAMICS
METHODS FOR STUDYING PROTEIN DYNAMICS
Non-Globular Proteins
INTRODUCTION
FIBROUS PROTEINS
INTRINSICALLY UNSTRUCTURED PROTEINS
Membrane Proteins
INTRODUCTION
STRUCTURE AND ORGANIZATION OF BIOLOGICAL MEMBRANES
PRINCIPLES OF MEMBRANE PROTEIN STRUCTURE
PROTEIN-MEMBRANE INTERACTIONS
STRUCTURE-FUNCTION RELATIONSHIP IN MEMBRANE PROTEINS AND PEPTIDES
Protein-Ligand Interactions
INTRODUCTION
THEORIES ON PROTEIN-LIGAND BINDING
PROTEIN-LIGAND BINDING ENERGETICS
THE LIGAND-BINDING SITE
PROTEIN-PROTEIN INTERACTIONS
PROTEIN-LIGAND INTERACTIONS IN DRUG ACTION AND DESIGN
Index
A Summary and References appear at the end of each chapter.
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