Basic aspects of catechol-O-methyltransferase and the clinical applications of its inhibitors

著者

    • Nissinen, Erkki

書誌事項

Basic aspects of catechol-O-methyltransferase and the clinical applications of its inhibitors

edited by Erkki Nissinen

（International review of neurobiology, v. 95）

Elsevier Academic Press, c2010

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

目次

Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson's disease with dual enzyme inhibition Erkki Nissinen The catechol-O-methyltransferase gene, its regulation and polymorphisms Elizabeth M. Tunbridge Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture? Timo T. Myoehanen & Pekka T. Mannistoe Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms Thomas Muller Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors Erkki Nissinen and Pekka T. Mannistoe The Chemistry of Catechol-O-methyltransferase Inhibitors David A. Learmonth, Laszlo E. Kiss and Patricio Soares-da-Silva Toxicology and safety of COMT inhibitors Kristiina Haasio Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment Concepcio Marin, J.A. Obeso Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease Seppo Kaakkola Catechol-O-methyltransferase and pain Oleg Kambur & Pekka T. Mannistoe

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  • International review of neurobiology

    Academic Press 1959-

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