Medaka : a model for organogenesis, human disease, and evolution
著者
書誌事項
Medaka : a model for organogenesis, human disease, and evolution
Springer, c2011
- : pbk
大学図書館所蔵 全12件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Oryzias latipes, known as medaka, is a model organism from East Asia. Breeding of this small, egg-laying freshwater teleost fish has long been popular among hobbyists in Japan. Now, as biological science has entered the genome era, the medaka provides significant advantages that make it one of the most valuable vertebrate models: a large collection of spontaneous mutants collected over a century, the presence of highly polymorphic inbred lines established over decades, and a recently completed genome sequence. This book is the first comprehensive monograph to cover a variety of medaka research. It opens with a historical view of medaka, followed by a series of research topics in the four major areas where the medaka is increasingly important: genomics, genetics, and resources; organogenesis and disease models; germ cells, sex determination, and reproduction; and evolution. Readers will find state-of-the-art information on medaka genetics and genomics such as the first isolation of active transposons in vertebrates, the influence of chromatin structure on sequence variation, fine QTL analysis, and versatile mutants as human disease models.
目次
1 A Glance at the Past of Medaka Fish Biology.-Part I Genomics, Genetics, and Resources.-2 Genetics, Genomics, and Biological Resources in the Medaka, Oryzias latipes.-3 Chromatin-Associated Periodicity in Genetic Variation Downstream of Transcriptional Start Sites.-4 Transposable Elements Tol1 and Tol2 5 A Systematic Screen for Mutations Affecting Organogenesis in Medaka.-Part II Organogenesis and Disease Models.-6 Medaka Bone Development.-7 Anatomical Atlas of Blood Vascular System of Medaka.-8 Kidney Development, Regeneration, and Polycystic Kidney Disease in Medaka.-9 Primary Ciliary Dyskinesia in Fish: The Analysis of a Novel Medaka Mutant Kintoun.-10 p53-Defi cient Medaka Created by TILLING.-11 Medaka Spontaneous Mutants for Body Coloration.-12 Craniofacial Traits.-13 Double Anal Fin (Da): A Medaka Mutant Exhibiting a Mirror-Image Pattern Duplication of the Dorsal-Ventral Axis.-Part III Germ Cells, Sex Determination, and Reproduction.-14 Interaction of Germ Cells and Gonadal Somatic Cells During Gonadal Formation.-15 Frequent Turnover of Sex Chromosomes in the Medaka Fishes.-16 Function of the Medaka Male Sex-Determining Gene.-17 The Sex-Determining Gene in Medaka.-18 Endocrine Regulation of Oogenesis in the Medaka, Oryzias latipes.-19 Interspecifi c Medaka Hybrids as Experimental Models for Investigating Cell Division and Germ Cell Development.-Part IV Evolution.-20 Reconstruction of the Vertebrate Ancestral Genome Reveals Dynamic Genome Reorganization in Early Vertebrates.-21 Genome Duplication and Subfunction Partitioning: Sox9 in Medaka and Other Vertebrates.-22 Human Population Genetics Meets Medaka.-23 Evolution of the Major Histocompatibility Complex: A Lesson from the Oryzias Species.-24 Molecular Evolution of Teleostean Hatching Enzymes and Their Egg Envelope Digestion Mechanism: An Aspect of Co-Evolution of Protease and Substrate.-Index.
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