Clinical trial design : Bayesian and frequentist adaptive methods
著者
書誌事項
Clinical trial design : Bayesian and frequentist adaptive methods
(Wiley series in probability and mathematical statistics)
Wiley, c2012
- : cloth
大学図書館所蔵 全12件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references (p. 311-327) and indexes
内容説明・目次
内容説明
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods
There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics.
Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include:
Risk and benefit analysis for toxicity and efficacy trade-offs
Bayesian predictive probability trial monitoring
Bayesian adaptive randomization
Late onset toxicity and response
Dose finding in drug combination trials
Targeted therapy designs
The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials.
Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
目次
Preface xv 1. Introduction 1
2. Fundamentals of Clinical Trials 13
3. Frequentist versus Bayesian Statistics 29
4. Phase I Trial Design 77
5. Phase II Trial Design 115
6. Phase III Trial Design 159
7. Adaptive Randomization 223
8. Late-Onset Toxicity 253
9. Drug-Combination Trials 271
10. Targeted Therapy Design 297
References 311
Author Index 329
Subject Index 333
「Nielsen BookData」 より