G protein coupled receptors : modeling, activation, interactions and virtual screening
Author(s)
Bibliographic Information
G protein coupled receptors : modeling, activation, interactions and virtual screening
(Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 522)
Elsevier/Academic Press, c2013
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Note
Includes bibliographical references and indexes
Description and Table of Contents
Description
This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation.
Table of Contents
GPCR Modeling
The Protein Local Optimization Program and G-Protein Coupled Receptors: Loop Restoration and Applications to Homology Modeling
Modeling Active GPCR Conformations
Molecular Modeling of Adenosine Receptors
Predicting G Protein-Coupled Receptors Families using Different Physiochemical Properties and Pseudo Amino Acid Composition
Computational Design and Experimental Characterization of GPCR Segment Models
GPCR Interactions with Other Molecules and Cross-Talk
G Protein-Coupled Receptor Interaction with Small GTPases
Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G Protein Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA)
NMR Methods for Detection of Small Molecule Binding to RGS4
Group II Activators of G-protein Signaling: Monitoring the Interaction of Ga with the G-Protein Regulatory Motif in the Intact Cell
Homogeneous Time-Resolved Fluorescence Assay to Probe Folded G Protein-Coupled Receptors
cAMP Biosensors Applied in Molecular Pharmacological Studies of G Protein-Coupled Receptors
Rhodopsin-Lipid Interactions Studied by NMR
GPCR Bias
Biasing the Parathyroid Hormone Receptor: Relating In Vitro Ligand Efficacy to In Vivo Biological Activity
Virtual Screening
Application of Monte Carlo-based Receptor-Ensemble Docking to Virtual Screening for GPCR Ligands
From Heptahelical Bundle to Hits from the Haystack: Structure-Based Virtual Screening for GPCR Ligands
GPCR Activation
Kinetics and Dynamics in the G-Protein Coupled Receptor Signaling Cascade
Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of G Protein-Coupled Receptors
Post-Translation Modification of G Protein-Coupled Receptor in Relationship to Biased Agonism
Protein S-Nitrosylation Measurement
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