G protein coupled receptors : modeling, activation, interactions and virtual screening

著者

• Conn, P. Michael

書誌事項

G protein coupled receptors : modeling, activation, interactions and virtual screening

edited by P. Michael Conn

（Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 522）

Elsevier/Academic Press, c2013

注記

Includes bibliographical references and indexes

内容説明・目次

内容説明

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation.

目次

GPCR Modeling The Protein Local Optimization Program and G-Protein Coupled Receptors: Loop Restoration and Applications to Homology Modeling Modeling Active GPCR Conformations Molecular Modeling of Adenosine Receptors Predicting G Protein-Coupled Receptors Families using Different Physiochemical Properties and Pseudo Amino Acid Composition Computational Design and Experimental Characterization of GPCR Segment Models GPCR Interactions with Other Molecules and Cross-Talk G Protein-Coupled Receptor Interaction with Small GTPases Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G Protein Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA) NMR Methods for Detection of Small Molecule Binding to RGS4 Group II Activators of G-protein Signaling: Monitoring the Interaction of Ga with the G-Protein Regulatory Motif in the Intact Cell Homogeneous Time-Resolved Fluorescence Assay to Probe Folded G Protein-Coupled Receptors cAMP Biosensors Applied in Molecular Pharmacological Studies of G Protein-Coupled Receptors Rhodopsin-Lipid Interactions Studied by NMR GPCR Bias Biasing the Parathyroid Hormone Receptor: Relating In Vitro Ligand Efficacy to In Vivo Biological Activity Virtual Screening Application of Monte Carlo-based Receptor-Ensemble Docking to Virtual Screening for GPCR Ligands From Heptahelical Bundle to Hits from the Haystack: Structure-Based Virtual Screening for GPCR Ligands GPCR Activation Kinetics and Dynamics in the G-Protein Coupled Receptor Signaling Cascade Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of G Protein-Coupled Receptors Post-Translation Modification of G Protein-Coupled Receptor in Relationship to Biased Agonism Protein S-Nitrosylation Measurement

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詳細情報

• NII書誌ID(NCID): BB1204139X
• ISBN:
  • 9780124078659
• 出版国コード: ne
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Amsterdam ; Tokyo
• ページ数/冊数: lvi, 472 p., [12] p. of plates
• 大きさ: 24 cm
• 件名:
  • LCSH : Cell receptors -- Structure-activity relationships
  • LCSH : G proteins -- Receptors
• 親書誌ID:
  • BA00197543