CiNii Books - Peripheral nerve disorders

Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities.

Table of Contents

Section 1 Introduction 1. Prelude to the peripheral neuropathies Section 2 Structure and function 2. Microscopic anatomy: normal structures
3. Gross anatomy and development of the peripheral nervous system
4. Physiology and pathophysiology of myelinated nerve fibers
5. Biology of Schwann cells
6. Neurophysiological approach to disorders of peripheral nerve
7. Testing autonomic functions
8. Imaging of the peripheral nervous system
9. The nerve biopsy: indications, technical aspects and contribution
10. The cutaneous nerve biopsy: Technical aspects, indications, and contribution
11. Antibody testing in peripheral nerve disorders
12. DNA testing in hereditary neuropathies Section 3 Clinical aspects 13. Examination and clinical care of the patient with neuropathy
14. How to explore a patient with chronic axonal neuropathy
15. Evaluation of a patient with suspected chronic demyelinating polyneuropathy
16. Sensory-motor assessment in clinical research trials
17. Management of painful neuropathies Section 4 Plexus and compression lesions 18. Diagnosis of brachial and lumbosacral plexus lesions
19. Compression and entrapment neuropathies
20. Facial nerve palsy and hemifacial spasm Section 5 Inflammatory root and nerve lesions 21. The Guillain-Barre syndrome
22. Chronic inflammatory demyelinating polyneuropathy
23. Treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
24. Multifocal motor neuropathy 25. Neuropathy and monoclonal gammopathy Section 6 Neuropathy in connective tissue disorders 26. Vasculitic neuropathy
27. Sarcoidosis of the peripheral nervous system Section 7 Neuropathy in infectious disorders 28. Leprous neuropathy
29. HIV peripheral neuropathy
30. Human t-cell leukemia virus (HTLV) associated neuropathy
31. Herpes virus infection of the peripheral nervous system
32. Lyme neuroborreliosis Section 8 Neuropathy and metabolic disorders 33. Diabetic neuropathy
34. Biology of diabetic neuropathy
35. Uremic neuropathy
36. Porphyric neuropathy
37. Fabry's disease
38. Transthyretin familial amyloid polyneuropathy
39. Hereditary gelsolin amyloidosis Section 9 Neuropathy and malignancy 40. Malignant cell infiltration in the peripheral nervous system
41. Paraneoplastic neuropathy Section 10 Cryptogenic, Traumatic and Iatrogenic neuropathies 42. Drug induced neuropathies
43. Late radiation injury to peripheral nerves
44. Neuromuscular complications of critical illness
45. The surgery of peripheral nerves (including tumours)
46. Neuropathy in the elderly Section 11. Familial neuropathies 47. Dominant Charcot-Marie-Tooth syndrome and cognate disorders
48. Recessively transmitted predominantly motor neuropathies
49. Early onset childhood monogenic neuropathies
50. Hereditary sensory and autonomic neuropathies
51. Peripheral nerve involvement in hereditary cerebellar and multisystem degenerative disorders
52. Giant axonal neuropathy
53. Neurofibromatosis 1(NF1), diagnosis and management
54. Neurofibromatosis type 2 (NF2) diagnosis and management

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Peripheral nerve disorders

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