Applications in organic synthesis

著者

• Grubbs, Robert Howard
• O'Leary, Daniel J.

書誌事項

Applications in organic synthesis

edited by Robert H. Grubbs and Daniel J. O'Leary

（Handbook of metathesis, v. 2）

Wiley-VCH, c2015

2nd ed

注記

Includes bibliographical references and index

内容説明・目次

内容説明

The second edition of the "go-to" reference in this field is completely updated and features more than 80% new content, with emphasis on new developments in the field, especially in industrial applications. No other book covers the topic in such a comprehensive manner and in such high quality. Edited by the Nobel laureate R. H. Grubbs and D. J. OLeary, Volume 2 of the 3-volume work focusses on applications in organic synthesis. With a list of contributors that reads like a "Who's-Who" of metathesis, this is an indispensable one-stop reference for chemists in academia and industry. View the set here - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527334246.html Other available volumes: Volume 1: Catalyst Development and Mechanism, Editors: R. H. Grubbs and A. G. Wenzel - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339485.html Volume 3: Polymer Synthesis, Editors: R. H. Grubbs and E. Khosravi - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339507.html

目次

About the Editors xxxiii Preface xxxvii List of Contributors of Volumes 1 and 2 xxxix Abbreviations and Acronyms xli Theory and instrumentation of mass spectrometry and its application to drug metabolism 393 Stacy L. Gelhaus and Ian A. Blair Mass spectral interpretation 419 Li-Kang Zhang and Birendra N. Pramanik Computational approaches in drug biotransformation studies: metabolite prediction 457 Nigel J. Waters and Michelle K. Dennehy High-throughput metabolite detection and quantitative-qualitative bioanalysis 481 Donghui Cui and Sean Yu Metabolic stability screen in drug discovery 499 Chuang Lu Application of triple-quadrupole and its hybrid mass spectrometers for the identification of drug metabolites 523 Zhi-Yi Zhang, Chandra Prakash, and Lin Xu Role of ion trap LC-MS techniques for the identification of drug metabolites 553 Robert D. Pelletier and W. George Lai Drug metabolite identification with high-resolution mass spectrometry 567 Haiying Zhang and Mingshe Zhu Strategies for the identification of unusual and novel metabolites using derivatization, hydrogen-deuterium exchange (HDX), and liquid chromatography-nuclear magnetic resonance (LC-NMR) spectroscopy techniques 591 Amin Kamel, Shawn Harriman, and Chandra Prakash The use of nanoelectrospray mass spectrometry for the quantitation of metabolites in the absence of synthetic standards 619 Jing-Tao Wu Quantitation of drug metabolites by radioactivity detection including accelerator mass spectrometry (AMS) 633 Angus N.R. Nedderman and Mark E. Savage Application of quantitative NMR in drug metabolism studies 661 Abdul E. Mutlib Early assessment of exposure of drug metabolites in humans using mass spectrometry 693 Natalia A. Penner, Joanna Zgoda-Pols, and Chandra Prakash Profiling and characterization of bioactive substances of herbal medicine and their metabolites using mass spectrometry 723 Xiaoyan Chen Application of in silico metabolism and environmental degradation data to support chemical PBT assessment 787 Sabcho Dimitrov, Gilman Veith, and Ovanes Mekenyan

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詳細情報

• NII書誌ID(NCID): BB19130046
• ISBN:
  • 9783527339495
• 出版国コード: gw
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Weinheim
• ページ数/冊数: xxvi, 743 p.
• 大きさ: 25 cm
• 親書誌ID:
  • BB19137205