Antibiotics : challenges, mechanisms, opportunities

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書誌事項

Antibiotics : challenges, mechanisms, opportunities

by Christopher Walsh and Timothy Wencewicz

ASM Press, c2016

大学図書館所蔵 件 / 全4件

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注記

Includes bibliographical references (p. 421-454) and index

内容説明・目次

内容説明

Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: * What are antibiotics? * Where do antibiotics come from? * How do antibiotics work? * Why do antibiotics stop working? * How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.

目次

Preface ix-x Section I Challenges for Antibiotics 1 1 Antibiotics: Initial Concepts and Considerations 4 2 Major Classes of Antibiotics and Their Modes of Action 16 Section II Mechanisms: Antibiotic Action by Bacterial Target Class 33 3 Assembly of the Peptidoglycan Layer of Bacterial Cell Walls 36 4 Antibiotics That Block Peptidoglycan Assembly and Integrity 68 5 Antibiotics That Disrupt Membrane Integrity 102 6 Antibiotics That Block Protein Synthesis 114 7 Antibiotics That Target DNA and RNA Information Transfer 148 8 Antibiotics That Block Biosynthesis of the DNA Building Block Deoxythymidylate 164 Section III Mechanisms: Bacterial Resistance to Antibiotics 177 9 Bacterial Antibiotic Resistance: Overview 180 10 Antibiotic Resistance: Modification or Destruction of the Antibiotic 198 11 Antibiotic Resistance via Membrane Efflux Pumps 220 12 Resistance via Target Modification 230 13 Tuberculosis: A Formidable Challenge for Antibiotic Therapy 252 Section IV Mechanisms: Antibiotic Biosynthesis 273 14 Antibiotic Biosynthesis: Principles 276 15 Biosynthesis of Peptide Antibiotics 288 16 Biosynthesis of Polyketide Antibiotics 320 17 Biosynthesis of Oligosaccharide, Isoprenoid, and C-P Antibiotic Classes 344 Section V Opportunities 363 18 Underexploited Pathways and Targets for Antibiotics 366 19 Prospects for New Molecules and New Targets 398 References 421 Index 455

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