Pharmaceutical inhalation aerosol technology

著者

書誌事項

Pharmaceutical inhalation aerosol technology

edited by Anthony J. Hickey, Sandro R. P. da Rocha,

（Drugs and the pharmaceutical sciences）

CRC Press, c2019

3rd ed

大学図書館所蔵 件 / 全3件

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注記

Includes bibliographies and index

内容説明・目次

内容説明

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery. Key Features: Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery Addresses the physics, chemistry and engineering principles while establishing disease relevance Expands the 'technology' focus of the original volumes to address the title more directly Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors

目次

Introduction Discovery - pharmacology and physiology Aerosol critical attributes - aerodynamic behavior, lung deposition and clearance Active Pharmaceutical Ingredient/Drug Product manufacturing Particle Engineering and Processing - milling, blending, spray drying, supercritical fluid, nano Drug Product Formulation Devices - design and performance Drug Product Formulation Product testing - physico-chemical properties, aerodynamic particle size, delivered dose Regulatory considerations - CMC Preclinical testing - dosing for cells and animals Clinical testing - concepts of bioequivalence General Conclusion

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