Progress in molecular and subcellular biology

著者

• Agranoff, B. W.
• Jeanteur, J.
• Hahn, F. E. (Fred Ernest)

書誌事項

Progress in molecular and subcellular biology

B. W. Agranoff ... [et al.]

Springer, 1969-

• v. 1
• v. 3 : gw
• v. 3 : us
• v. 4 : gw
• v. 4 : us
• v. 5 : gw
• v. 5 : us
• v. 6 : gw
• v. 6 : us
• v. 7 : gw
• v. 7 : us
• v. 8 : gw
• v. 8 : us
• v. 9 : gw
• v. 9 : us
• v. 10 : gw
• v. 10 : us
• v. 11 : gw
• v. 11 : us
• v. 12 : gw
• v. 12 : us
• v. 14 : gw
• v. 14 : us

注記

v. 9 / edited by F. E. Hahn ...[et al.]

v. 10 / edited by J. Jeanteur ... [et al.]

v. 14 / edited by P. Jeanteur ... [et al.]

内容説明・目次

巻冊次

v. 3 : gw ISBN 9783540062271

目次

Reverse Transcription and the Central Dogma.- I. Introduction.- II. Cryptology and the Central Dogma.- III. Reverse Transcription: Experimental Evidence.- IV. Reverse Transcription and Cancer.- V. Is There Reverse Transcription in Bacteria?.- VI. Biological Significance of Reverse Transcription.- VII. Cryptography and the Central Dogma.- VIII. Conclusion.- IX. Glossary of Terms.- References.- X. Addendum.- The Isolation of Genes: A Review of Advances in the Enrichment, Isolation and in vitro Synthesis of Specific Cistrons.- I. Introduction.- II. Procedures for the Preparation of Specific Cistrons.- III. Conclusion.- References.- Mechanism of Protein Synthesis and the Use of Inhibitors in the Study of Protein Synthesis.- I. Introduction.- II. Initiation of Protein Synthesis.- III. Chain Elongation.- IV. Chain Termination.- V. Epilogue.- References.- Structural Features of Immunoglobulin Light Chains.- I. Introduction.- II. Association of Light Chains.- III. Thermal Behavior of Bence-Jones Proteins.- IV. Distribution of Polar and Apolar Residues in Amino Acid Sequences of Light Chains.- V. Criteria of Purity in the Bence-Jones Protein Used in the Crystallographic Study.- VI. Crystallography of the Mcg Bence-Jones Protein.- VII. Discussion.- VIII. Summary.- References.- The Thalassemia Syndromes: Genetically Determined Disorders of the Regulation of Protein Synthesis in Eukaryotic Cells.- I. Introduction.- II. The Beta Thalassemias: Clinical Picture and Pathogenesis of Anemia.- III. The Molecular Basis of the Suppression of Beta Chain Synthesis in Severe Beta Thalassemia.- Appendix I: The Alpha Thalassemias.- Appendix II: The Lepore-Pylos Hemoglobins.- References.- The Mitochondrial DNA of Malignant Cells.- I. Introduction.- II. Morphology of Mitochondria in Malignant Cells.- III. Size and Structure of Mitochondrial DNA in Malignant Cells.- IV. Synthesis of Mitochondrial DNA in Malignant Cells: Content, Rate and Mechanism.- V. Is the Informational Content of Mitochondrial DNA Modified in Malignant Cells?.- VI. Are the Changes in Mitochondrial DNA in Malignant Cells Under Genetic Control?.- VII. Are the Changes in Mitochondrial DNA Related to Some Energy Imbalance in Mitochondria of Malignant Cells?.- VIII. Are the Changes Observed in Mitochondrial DNA of Malignant Cells Specific of Malignancy?.- IX. Concluding Remarks.- Appendix I. Isolation and Examination of Mitochondrial DNA.- Appendix II. DNA Circular Oligomers other than Mitochondrial.- References.

巻冊次

v. 4 : gw ISBN 9783540074878

目次

The Polymorphism of DNA.- I. Introduction.- II. A Summary of the Principles of DNA X-Ray Diffraction.- III. Generalities of DNA Transitions.- IV. B-like Structures.- V. The A Form.- VI. C-like Structures.- VII. Polynucleotide Polymorphism.- VIII. New Conformations of AT-rich DNA.- IX. Biological Relevance.- References.- Regulation of Bacteriophage T4 Gene Expression.- I. Introduction.- II. The Genetic Map of Coliphage T4.- III. Resolution of the Early and Late Classes of T4- specific RNA.- IV. Resolution of the Quasi-late RNA.- V. Immediate-early and Delayed-early RNAs.- VI. Transcription of the Prereplicative Genes of Bacteriophage T4: The Read-through Mechanism.- VII. Delayed-early Promoters.- VIII. The Interrelationship between Translation and Elongation of Chains from Immediate-early Promoters.- IX. Requirements for True-late Transcription.- X. Transcription of the Quasi-late Genes.- XI. Turn-off of Early Gene Expression.- XII. T4-specific Modifications of DNA-dependent RNA Polymerase.- XIII. T4-specific Modification of the Host Translational Machinery.- XIV. Expression of the Endolysin Gene of Phage T4.- References.- Defective Bacteriophages: The Phage Taillike Particles.- I. Introduction.- II. Structure.- III. Production.- IV. Bactericidal Activity.- V. Evolution.- VI. Conclusions.- References.- The Genesis of Multicellular Organization and the Control of Gene Expression in Diotyostelium discoideum.- I. Introduction.- II. The Migrating Slug.- III. Cell Association as an Initiator of Gene Expression.- IV. c-AMP, c-AMPsites, and the Morphogenetic Field of D. discoideum.- References.- Isoprenoids and Bacteriorhodopsin in Halobacteria.- I. Introduction.- II. General Features of Halobacteria.- III. Biosynthesis of Isoprenoid Compounds.- IV. The Purple Membrane and Bacteriorhodopsin.- V. The Photochemical Cycle in Bacteriorhodopsin.- VI. Function of Bacteriorhodopsin in the Halobacterial Cell.- VII. Biosynthesis of Bacteriorhodopsin and the Purple Membrane.- References.- Inhibitors of DNA Synthesis in RNA Tumor Viruses: Biological Implications and Their Mode of Action.- I. Introduction.- II. Requirements for DNA Synthesis by RNA Tumor Viruses.- III. Inhibition of Oncogenesis by RNA Tumor Viruses.- IV. Conclusion and Future Prospects.- References.- Adenosine as a Physiological Regulator of Coronary Blood Flow.- I. Introduction.- II. Control of Adenosine Production in Mammalian Heart.- III. Regulation of the Size of Cardiac Adenosine Pool.- IV. Adenosine Relaxation of Coronary Smooth Muscle.- V. Summary.- References.

巻冊次

v. 5 : gw ISBN 9783540081920

目次

Thermal Transition Spectroscopy: A New Tool for Submolecular Investigation of Biologic Macromolecules.- I. Introduction.- II. Results.- III. Application of the Method to the Study of DNA-Containing Complexes.- References.- Interactions of Drugs with Liver Microsomes.- I. Introduction.- II. Structural and Chemical Organization of Liver Microsomes.- III. Interaction of Drugs with the Microsomal Lipid Fraction.- IV. Interactions of Drugs with Microsomal Proteins.- V. Effects of Drugs on Microsomal Constitution and Activities.- VI. Summary and Concluding Remarks.- References.- The Pathogenesis of Experimental Acute Renal Failure: The Role of Membrane Dysfunction.- I. Introduction.- II. Heavy Metal-Induced Alterations in Membrane Function.- III. The Renin-Angiotensin System.- IV. Renal Hemodynamics and Acute Renal Failure.- V. Synthesis.- References.- Three-Dimensional Pharmacophoric Pattern Searching.- I. Introduction.- II. Quantitative Structure-Activity Relationships.- III. Description of Pharmacophoric Patterns.- IV. Three-Dimensional Pharmacophoric Pattern Searching.- V. Pattern Matching Applications.- VI. Conclusions.- References.- Chemical Evolution: A Terrestrial Reassessment.- I. Introduction.- II. Development of the Terrestrial Environment.- III. Further Chemical Evolutionary Hierarchies.- IV. Terrestrial Life: Chance or Circumstance.- V. Conclusion.- References.- Supplementary Bibliography.

巻冊次

v. 6 : gw ISBN 9783540085881

目次

DNA Cloning and the Analysis of Plasmid Structure and Function.- A. Introduction.- B. Restriction Endonucleases.- C. DNA Cloning.- D. Analysis of Plasmid Structure and Function.- E. Concluding Remarks.- References.- Peptide Bond Formation in Non-ribosomal Systems.- A. Introduction.- B. Recent Developments in Non-ribosomal Peptide Formation.- C. Coding Capacity of Non-ribosomal Systems.- References.- Opiate Receptors and Their Endogenous Ligands (Endorphins).- Opiate Receptors.- A. Introduction.- B. Properties of Opiate Receptors as Inferred from in vivo Studies.- C. Receptor Binding of Opiate Drugs in Tissue Homogenates.- D. Location of Opiate Receptors.- E. Opiate Receptor Isolation.- F. Opiate Receptor-Mediated Effects on Peripheral Autonomic Neuroeffector Transmission.- G. Opiate Receptor-Mediated Effects on the Synthesis of Cyclic Nucleotides.- Endorphins.- A. History.- B. Structures of the Endorphins Contained in ?-LPH.- C. Other Endorphins.- D. Structure-Activity Relationships.- E. Distribution of the Endorphins.- F. Pharmacology and Physiology of the Endorphins.- References.- Influence of DNA Complexing Compounds on the Kinetoplast of Trypanosomatids.- A. Introduction.- B. Classification and Developmental Stages.- C. Structural Organization of the kDNA.- D. Replication of the kDNA.- E. Function of the kDNA.- F. Dyskinetoplasty in the Trypanosomatidae.- G. Chemotherapy of Trypanosomiasis and kDNA Binding Drugs.- H. Intercalating Compounds.- I. Non-Intercalating Compounds.- J. Conclusions.- References.- Mechanisms of Lymphocyte Transformation.- A. Introduction.- B. Cellular Interactions.- C. Interactions of Mitogens with Lymphocytes.- D. Cellular Commitment to Transformation.- E. Surface Changes and Transmembrane Events.- F. Energy Metabolism.- G. Cyclic Nucleotides and Lymphocyte Transformation.- H. Alterations in Genetic Expression.- I. Mitogen-Induced DNA Synthesis.- K. Termination of Proliferation.- L. Conclusions.- References.- Effects of Drugs on Chloroplasts.- A. Introduction.- B. Sensitivity of Chloroplasts to Exogenous Factors.- C. Some Modern Support of the Theory of Prokaryotic Origin of Chloroplasts.- D. Antibiotics Inducing Hereditary Bleaching of Euglena gracilis.- E. Attempt to Explain the Mechanism of Induction of Hereditary Loss of Chloroplasts.- F. General Conclusions.- References.

巻冊次

v. 7 : gw ISBN 9783540101505

目次

The Photochemistry of 5-Bromouracil and 5-Iodouracil in DNA (With 2 Figures).- A. Introduction.- B. Structural and Spectroscopic Information.- C. Ultraviolet-induced Lesions in DNA Containing BrUra.- D. Biological Effects of BrUra and IUra Photoproducts.- E. Uses of the Photochemistry of Bromouracil in Biology.- F. Differential Staining of Sister Chromatids Containing BrUra 24.- G. Incorporation of Halouracils in DNA.- H. Relationship Between Other Biological Effects of the Halouracils and Photochemical Effects.- References.- Non-Intercalative Binding to DNA (With 2 Figures).- A. Introduction.- B. Poly-L-Lysine.- C. Spermine and Related Polyamines.- D. Distamycin A and Netropsin.- E. Methyl Green.- F. Other Non-Intercalators.- G. Discussion and Conclusions.- References.- The Amatoxins (With 3 Figures).- A. Introduction.- B. Occurrence and Structure.- C. Toxicity.- D. Inhibition of RNA Polymerase in Vitro.- E. Molecular Interaction with RNA Polymerase.- F. Structural Lesions in Nuclei.- G. Lesions Induced in In-Vivo Systems.- H. Penetration into Various Cells.- I. Resistant Cell Lines.- J. Virus Research.- K. Hormonal Research.- L. Developmental Studies.- M. Behavioral Research.- References.- Specialized Genetic Recombination Systems in Bacteria: Their Involvement in Gene Expression and Evolution (With 21 Figures).- A. Introduction.- B. Genetic Recombination: An Overview.- C. Specialized Recombination Systems in Bacteria.- D. Effect of Transposable Elements and Viruses on Bacterial Evolution.- E. Use of Transposable Elements as Experimental Tools.- F. Specialized Recombination in Eukaryotic Cells: A Prologue.- References.- Viroids (With 3 Figures).- A. Introduction.- B. Physical and Chemical Properties of Viroids.- C. Replication of Viroids.- D. Possible Mechanisms of Pathogenesis.- E. Possible Origin of Viroids.- References.

巻冊次

v. 8 : gw ISBN 9783540125907

目次

Penicillin Until 1957.- A. Introduction.- B. The Discovery of Penicillin.- C. Penicillin as a Chemotherapeutic Drug.- D. Early Studies on Mode of Action.- E. Paradoxical Inhibitory Zone Phenomena.- F. Morphological Changes in Bacteria.- G. Bacterial Lysis by Penicillin.- H. Interference of Penicillin with Nucleic Acid and Protein Synthesis?.- I. Park's Nucleotides.- J. Penicillin Binding by Bacteria.- References.- The Role of Inducible DNA Repair in W-Reactivation and Related Phenomena.- A. Introduction.- B. Enzymatic Repair Systems in Bacteria and Their Viruses.- C. W-Reactivation and W-Mutagenesis.- D. Direct and Indirect Prophage Induction.- E. Plasmid Mediated UV-Protection and Mutagenesis.- F. Inducible "SOS"-Repair Functions.- References.- Biological and Biochemical Actions of Trichothecene Mycotoxins.- A. Introduction.- B. Trichothecene Structure and Genesis.- C. Detection of Trichothecenes.- D. Trichothecene Production.- E. Human and Animal Mycotoxicoses in which Trichothecenes are the Suspected Causative Agents.- F. Biological Activity of the Trichothecenes.- G. Biochemical Studies on the Action of Trichothecenes.- H. Physiological Mechanisms of Trichothecene Toxicity.- I. Metabolism of Trichothecenes.- J. Trichothecenes - Pharmaceuticals or Chemical Weapons.- References.- The Scrapie Agent: A Unique Self-Replicating Pathogen.- A. Introduction.- B. Biology.- C. Biochemical Characterization.- D. Theoretical Considerations for a Self-Regulated Protein Pathogen.- E. Future Directions.- References.- Non-Cholinesterase Effects of Anticholinesterases.- A. Background.- B. Neuropeptides.- C. Conclusion.- References.

巻冊次

v. 9 : gw ISBN 9783540150718

目次

snRNP's and scRNP's in Eukaryotic Cells (With 4 Figures).- A. Historical Background.- B. The U snRNA's.- C. Other Small RNA's Precipitable with Autoimmune Antibodies.- D. Other Small RNP's of Organized Function.- E. Concluding Remarks.- References.- Nucleotide-specific Ribonucleases from Eukaryotes. Their Possible Roles During Poly (A) (+) mRNA Maturation and Degradation (With 12 Figures).- A. Introduction.- B. Posttranscriptional Events in mRNA Maturation.- C. Eukaryotic Ribonucleases: a Brief Survey.- D. Poly (A) Metabolism.- E. Splicing.- F. Role of Poly (A) Chain Length Controlled by Specific Nucleases and of snRNP's During Poly (A) (+) mRNA-nuclear Matrix Association and Nucleocytoplasmic Poly (A) (+) mRNA Transport.- G. Conclusion and Future Directions.- References.- The Cap Structure of Eukaryotic Messenger RNA and its Interaction with Cap-binding Protein (With 12 Figures).- A. Introduction.- B. 5' -Terminal Cap Structure of Messenger RNA.- C. The Dependence of Translation on the Cap Structure.- D. Identification of the Cap-binding Protein.- E. Involvement of Cap-binding Proteins in Initiation of Protein Synthesis.- F. Antibodies to Cap-binding Protein-related Polypeptides..- G. Effect of Virus Infection on Cap-binding Protein.- H. Cap-binding Protein and the Cytoskeleton.- I. Conclusion and Future Directions.- K. 1984 Addendum.- References.- Cell-Cell Recognition in Lower Multicellular Eukaryotes. Models Supporting the Modulation Theory of Adhesion (With 9 Figures).- A. Introduction.- B. Cell-Cell Adhesion in Vertebrates.- C. Cell Adhesion Molecules in Sponges.- D. Cell Recognition Molecules in Corals.- E. Conclusion.- References.

巻冊次

v. 10 : gw ISBN 9783540191704

目次

Translocation Along Microtubules in Insect Ovaries.- A. Introduction.- B. Insect Ovaries, Their Morphology and Development.- C. Translocation of Materials Between Nutritive Cells and Oocytes.- D. Ultrastructure of Nutritive Tubes.- E. Mechanisms of Microtubule-Associated Transport Along Nutritive Tubes.- F. The Motor(s) for Microtubule-Based Translocation.- References.- Nucleo-Cytoplasmic Transport of mRNA: Its Relationship to RNA Metabolism, Subcellular Structures and Other Nucleocytoplasmic Exchanges.- A. Introduction.- B. An Overview of Nucleocytoplasmic Transport.- C. RNA Metabolism and Ribonucleoprotein Structure.- D. Messenger RNA Transport.- E. The Control of Messenger Transport.- F. Conclusions.- References.- Prebiotic Evolution and the Origin of Life: Chemical and Biochemical Aspects.- A. The Object and Its History.- B. Modern Hypotheses, General Objections and Supports.- C. The Oparin Hypothesis and the Simulation Experiments.- D. The Origin of Genetic Information.- E. Conclusions.- References.

巻冊次

v. 11 : gw ISBN 9783540518327

内容説明

Biological functions are almost exclusively attributed to macromolecules, i.e. nucleic acids, proteins and polysaccharides. To gain their complete functional activities these biomolecules have to associate with the nuclear matrix, the cytoskeleton and the cell/plasma membranes. It is the aim of this series to discuss actual aspects in the field of structure-associated genetic and epigenetic functional processes. This series of survey reviews fills the gap in structure-associated information flow, and is a vital reference work for scientists in molecular and cell biology.

巻冊次

v. 12 : gw ISBN 9783540539001

内容説明

Biological functions are almost exclusively attributed to macromolecules, such as nucleic acids, proteins and polysaccharides. To achieve their complete functional activities these biomolecules have to associate with the cellular components, such as the nuclear matrix, cytoskeleton or cell/plasma membranes. Topics discussed in this volume include the synthesis of small nuclear RNAs, DNA-activated protein kinase, interactions of water and proteins in cellular functions, heat shock protein synthesis and the cytoskeleton during early development.

目次

Synthesis of Small Nuclear RNAs.- 1 Introduction.- 2 Two Classes of U snRNA Genes.- 3 RNA Polymerases Transcribing U snRNA Genes.- 3.1 TMG-Capped snRNAs.- 3.2 MepppG-Capped snRNAs.- 4 Organization of U snRNA Genes.- 4.1 Human.- 4.2 Rodent.- 4.3 Chicken.- 4.4 Xenopus.- 4.5 Drosophila.- 4.6 Sea Urchin.- 4.7 Trypanosome.- 4.8 C. elegans.- 4.9 Yeast.- 4.10 Plants.- 4.11 Viral U RNAs.- 5 Cis-Acting Elements in U snRNA Genes.- 5.1 Initiation Nucleotide.- 5.2 Proximal Sequence Element (PSE).- 5.3 TATA Box.- 5.4 Distal Sequence Element (DSE).- 5.5 3?-End Formation.- 6 Interconversion of U snRNA Promoters.- 6.1 SnRNA and mRNA Gene Promoters Are Distinct.- 6.2 Transcription of snRNA Genes in Vitro and in Heterologous Systems.- 7 Regulation of snRNA Synthesis.- 8 Formation of Cap Structure in U snRNAs.- 8.1 Signal for U6 snRNA Capping.- 8.2 Post-Transcriptional Capping of U6 snRNA.- 8.3 Other snRNAs with mepppG Cap Structure.- 8.4 Functions of Cap Structures.- 9 Summary.- References.- The DNA-Activated Protein Kinase, DNA-PK.- 1 Nuclear Protein Kinases.- 2 Nucleic Acid Effects on Protein Kinase Activity.- 3 Detection of DNA-Stimulated Protein Phosphorylation in Cell Extracts.- 4 Purification of DNA-PK from HeLa Cells.- 5 Physical Characteristics of DNA-PK.- 6 Subcellular Localization.- 7 Phosphate Donor and Cofactor Requirements.- 8 Effects of Inhibitors.- 9 Substrate Specificity.- 9.1 Autophosphorylation.- 9.2 Substrate Preference and Phosphorylation Sites.- 10 Effects of Polynucleotides.- 11 Occurrence of DNA-PK in Other Cells.- 12 Comparison with Other Nuclear Protein Kinases.- 13 Conclusions and Future Directions.- References.- The Cytoskeleton During Early Development: Structural Transformation and Reorganization of RNA and Protein.- 1 Introduction.- 2 The Cytoskeleton in the Early Development of Chordates.- 2.1 Ascidians.- 2.2 Amphibians.- 2.3 Mammals.- 3 The Cytoskeleton in the Early Development of Nonchordates.- 3.1 Annelids.- 3.2 Oligochaetes.- 3.3 Nematodes.- 3.4 Insects.- 3.5 Echinoderms.- 4 Conclusion.- References.- Developmental Regulations of Heat-Shock Protein Synthesis in Unstressed and Stressed Cells.- 1 Introduction.- 2 Expression of Heat-Shock Genes During Gametogenesis and Early Development in the Absence of Stress.- 2.1 An Ancient Developmental Response: Heat-Shock Protein Hyperexpression During Sporulation and Gametogenesis.- 2.2 Heat-Shock Proteins, First Major Products of the Zygotic Genome Transcription in Mammals.- 2.3 Constitutive Heat-Shock Protein Expression During Early Mouse Embryogenesis.- 2.4 Constitutive Heat-Shock Protein Expression in Mouse Embryonal Carcinoma (EC) Cells.- 2.5 High Levels of B2 Transcripts in Heat-Shocked Fibroblasts and in Undifferentiated Mouse Embryonic Cells.- 3 Heat-Shock Protein Synthesis in Differentiation Processes.- 3.1 Specificities of the Heat-Shock Protein Synthesis Associated with Blood Cell Differentiation.- 3.2 Hormone-Induced Heat-Shock Protein Expression.- 3.3 Entering or Leaving a Quiescent State.- 4 Deficient Heat-Shock Responses.- 4.1 Sporulation and Gametogenesis.- 4.2 Early Embryogenesis.- 4.3 Cultured Cells.- 5 Concluding Remarks.- References.- The Interactions of Water and Proteins in Cellular Function.- 1 Introduction.- 2 The Cluster Model of Liquid Structure.- 2.1 Cluster Size.- 2.2 Cluster Energetics.- 3 The Domain Model of Protein Structure.- 3.1 Domain Size.- 3.2 Domain Energetics.- References.

巻冊次

v. 14 : gw ISBN 9783540572855

内容説明

Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes the current knowledge of the interferon-based natural antiviral protection system, including 2',5'-oligoadenylate and double-stranded RNA. It should help to develop a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.

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詳細情報

• NII書誌ID(NCID): BA04061022
• ISBN:
  • 3540062270
  • 0387062270
  • 3540074872
  • 0387074872
  • 3540081925
  • 0387081925
  • 3540085882
  • 0387085882
  • 3540101500
  • 0387101500
  • 3540125906
  • 0387125906
  • 3540150714
  • 0387150714
  • 3540191704
  • 0387191704
  • 3540518320
  • 0387518320
  • 354053900X
  • 038753900X
  • 3540572856
  • 0387572856
• LCCN: 75079748
• 出版国コード: gw
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Berlin ; Tokyo
• ページ数/冊数: v.
• 大きさ: 26 cm