Frontiers in muscle research : myogenesis, muscle contraction and muscle dystrophy : proceedings of the Uehara Memorial Foundation Symposium on Frontiers in Muscle Research, Tokyo, 15-19 July, 1990

書誌事項

Frontiers in muscle research : myogenesis, muscle contraction and muscle dystrophy : proceedings of the Uehara Memorial Foundation Symposium on Frontiers in Muscle Research, Tokyo, 15-19 July, 1990

editors, Eijiro Ozawa, Tomoh Masaki, Yoichi Nabeshima

(International congress series, no. 942)

Excerpta Medica, 1991

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注記

Includes bibliographical references and indexes

内容説明・目次

内容説明

Researchers from various fields of muscle cell study gathered to exchange new knowledge and to show new trends in muscle sciences to the younger generation of scientists. Today, muscle research has many facets, i.e. induction of muscle from more immature tissues, control of gene expression, formation of organelles such as myofibrils, and contraction and maintenance of muscle cells. The constructive presentations and discussions presented by leading researchers in these various fields makes this book a reflection of the frontiers, and the developments in muscle science in 1990.

目次

Preface. Induction of Mesoderm and Muscle. The origin of muscle in early development: Cell and molecular mechanisms. Mesoderm induction in early amphibian embryos by activin A and its related gene products in Xenopus laevis. Activation of muscle genes in Xenopus by mesoderm-inducing factors. Embryonic induction and the transforming growth factor beta (TGF-beta) family: Activins induce axial structures and are expressed in early Xenopus embryos. Specification of myotomal muscle in the early development of Xenopus laevis. The regulation of myogenesis by MyoD and the helix-loop-helix proteins. The structure and function of myogenin. Control of Gene Expression. Muscle gene expression during embrogenesis in the mouse. The muscle-specific human cardiac alpha-actin promoter interacts with several regulatory proteins and is activated after direct interaction with the MyoD, Sp-1 and SRF activators. Transcriptional regulation of chicken myosin alkali light chain genes. Regulatory elements required for cell-specific activity of the cardiac troponin T gene promotor in early embryonic cardiac and skeletal muscle. Regulation of alternative splicing of contractile protein genes. Cell Lineage. Cell lineage and differentiation of muscle cells in prochordate embryos. The myoblast family and skeletal muscle development. Striated myoblasts and multinucleated myotubes induced in non-muscle cells by MyoD are similar to normal in vivo and in vitro counterparts. Myofibrillogenesis. Myosin binding proteins: Intracellular members of the immunoglobulin superfamily. Development of connectin (titin) and nebulin in cultured cardiac and skeletal muscle cells. Regulation of actin assembly in embryonic chicken muscle by three different actin-binding proteins. A nonmuscle alpha-actinin isoform and myofibrillogenesis. Natori's skinned fiber and excitation contraction coupling. Natori's skinned fiber. Brief overview of studies on the regulatory protein of muscle. Ordering mechanisms in striated muscle fibers. Connection, an elastic protein, in striated muscle. Dystropin. Formation of dystropin lining on muscle cell membrane in myogenesis in vivo. The dystrophin-glycoprotein complex: Identification and biochemical characterization. Isolation and characterization of dystrophin related proteins. Promoters and isoforms of transcripts of the DMD gene. Studies in muscular dystrophy: Dystrophin minigenes and dystrophin related proteins. From dystrophy to dystrophin: Tracing back structure to (dys) function. The defective gene and gene product in Duchenne muscular dystrophy. Molecular diagnosis of Duchenne/Becker muscular dystrophy. Index of authors. Subject index.

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