Neuronal degeneration and regeneration : from basic mechanisms to prospects for therapy
著者
書誌事項
Neuronal degeneration and regeneration : from basic mechanisms to prospects for therapy
（Progress in brain research, v. 117）
Elsevier, 1998
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注記
"Proceedings of the 20th International Summer School of Brain Research, held at the Royal Netherlands Academy of Sciences, Amsterdam, the Netherlands from 25 to 29 August 1997"
内容説明・目次
- 巻冊次
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series ISBN 9780444801043
内容説明
This volume is a cross-disciplinary reference on the behavioural, neurobiological and clinical aspects of eye movements. It includes a large body of new empirical work as well as the principal theoretical viewpoints of leading research groups in this field. Topics discussed in the book include the role of cortical and subcortical brain areas in control of saccadic eye movements, attentional mechanisms in guiding smooth pursuit eye movements, neural mechanisms related to eye-hand coordination, oculomotor deficits in psychiatric disorders, neural mechanisms related to hand-eye coordination and oculomotor deficits in psychiatric disorders, Parkinson's disease and head injury patients. this book addresses a wide audience and will be particularily of interest to researchers in neurophysiology and neuropsychology of vision.
目次
- Saccadic Eye Movements
- Change Blindness and Transsaccadic Integration
- Smooth Pursuit Eye Movements
- Eye-Hand Coordination
- Clinical Aspects of Eye Movement Research.
- 巻冊次
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ISBN 9780444828170
内容説明
This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases.The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.
目次
Chapter Headings: Section 1. Mechanisms of Nerve Cell Death and Nerve Cell Survival. Section 2. Biological Factors that Determine Neuronal Differentiation, Axonal Growth, Guidance and Target Recognition. Section 3. The Role of Glial Cells in Neurodegeneration and Regeneration. Section 4. Critical Events in Neurodegenerative Diseases, Prion Diseases and Multiple Sclerosis. Section 5. Strategies to Promote Regeneration of Injured Neurons: Direct Intervention and Neural Replacement.
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