Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding

書誌事項

Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding

Alan Fersht

W.H. Freeman, 1998, c1999

大学図書館所蔵 件 / 78

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Fersht's Structure and Mechanism in Protein Science is a defining exploration of this new era, an expert depiction of the core principles of protein structure, activity, and mechanism as understood and applied today. A thorough recasting of Fersht's previous text, the book takes a more general look at mechanisms in protein science, emphasizing the unity of concepts in folding and catalysis and the importance of the relationships between basic chemistry, kinetics, thermodynamics, and structure.

目次

  • The three-dimensional structure of proteins
  • chemical catalysis
  • the basic equations of enzyme kinetics
  • measurement and magnitude of enzymatic rate constants
  • the pH dependence of enzyme catalysis
  • practical kinetics
  • detection of intermediaries in reactions by kinetics
  • stereochemistry of enzymic reactions
  • active-site-directed and enzyme-activated irreversible inhibitors - affinity labels and suicide inhibitors
  • conformational change, allosteric regulation, motors and work
  • forces between molecules, and enzyme-substrate binding energies enzyme-substrate complementarity and the use of binding
  • energy in catalysis
  • specificity and editing mechanisms
  • recombinant DNA technology
  • case studies of enzyme structure and mechanism
  • protein engineering
  • protein stability
  • kinetics of protein folding
  • folding pathways and energy landscapes.

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