Nervous system plasticity and chronic pain
著者
書誌事項
Nervous system plasticity and chronic pain
（Progress in brain research, v. 129）
Elsevier, 2000
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注記
Includes bibliographies and index
内容説明・目次
内容説明
In this volume, the mechanisms underlying the various forms of neuropathic pain are explored by leading experts in the field, as pain researchers and pain therapists give insights into developments in an inter-disciplinary approach. The reviews provide up-to-date knowledge in pain research from the molecular and cellular level up to imaging of pain in the human cortex and to the perception of pain. Some symptoms of neuropathic pain can now be understood at the molecular level, for example, by modifications in the subunit composition of sodium channels or by the molecular properties of the vanilloid receptor. Synaptic mechanisms similar to those involved in learning and memory formation have now been discovered in pain pathways and real-time images of brain activity in human patients give novel insights into the differential processing of sensory-discriminative versus emotional-aversive aspects of pain. This volume also documents another achievement in pain research during the 1990s, the development of a common language and the assimilation of scientific concepts across disciplines.
目次
- I Molecular causes of chronic pain: Sodium channels and the molecular pathophysiology of pain, (T.R. Cummins, S.D. Dib-Hajj, J.A. Black and S.G. Waxman)
- Chemical mediators of pain due to tissue damage and ischemia, (S.P. Eckert, S.P. Cook and E.W. McCleskey)
- Nociceptor excitation by thermal sensitization - a hypothesis, (P.W. Reeh and G. Petho)
- Protein kinase subtypes involved in injury - induced nociception, (A.B. Malmberg)
- II Synaptic mechanisms of hyperalgesia and allodynia: Synaptic transmission and plasticity in the superficial dorsal horn, (K.A. Moore, H. Baba and C.J. Woolf)
- Synaptic mechanisms of hyperalgesia, (J. Sandkuhler, J. Benrath, C. Brechtel, R. Ruscheweyh and B. Heinke)
- Silent glutamatergic synapses and long-term facilitation in spinal dorsal horn neurons, (M. Zhuo, St. Louis)
- Spinal dorsal horn synaptic plasticity - involvement of group I metabotropic glutamate receptors, (G. Gerber, D.-H. Youn, C.H. Hsu and Randi C. Ames)
- (Part contents).
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