Cell cycle, proliferation, and cancer

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Bibliographic Information

Cell cycle, proliferation, and cancer

Avner Friedman (ed.) ; with contributions by B. Aguda ... [et al.]

(Lecture notes in mathematics, 1872 . Mathematical biosciences subseries . Tutorials in mathematical biosciences ; 3)

Springer , Mathematical Biosciences Institute at the Ohio State University, c2006

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Includes bibliographical references

Description and Table of Contents

Description

This volume introduces some basic mathematical models for cell cycle, proliferation, cancer, and cancer therapy. Chapter 1 gives an overview of the modeling of the cell division cycle. Chapter 2 describes how tumor secretes growth factors to form new blood vessels in its vicinity, which provide it with nutrients it needs in order to grow. Chapter 3 explores the process that enables the tumor to invade the neighboring tissue. Chapter 4 models the interaction between a tumor and the immune system. Chapter 5 is concerned with chemotherapy; it uses concepts from control theory to minimize obstacles arising from drug resistance and from cell cycle dynamics. Finally, Chapter 6 reviews mathematical results for various cancer models.

Table of Contents

Modeling the Cell Division Cycle (B. Aguda).- Angiogenesis - A Biochemical/Mathematical Prospective (H. A. Levine and M. Nilsen-Hamilton).- Spatio-Temporal Models of the uPA System and Tissue Invasion (G. Lolas).- Mathematical Modeling of Spatio-Temporal Phenomena in Tumor Immunology (M. Chaplain and A. Matzavinos).- Control Theory Approach to Cancer Chemotherapy: Benefiting from Phase Dependence and Overcoming Drug Resistance (M. Kimmel and A. Swierniak).- Cancer Models and their Mathematical Analysis (A. Friedman).

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