Parkinson's disease and related disorders
著者
書誌事項
Parkinson's disease and related disorders
（Handbook of clinical neurology, v. 83-84 = 3rd. ser. v. 5-[6]）
Elsevier, 2007
- pt. 1
- pt. 2
大学図書館所蔵 件 / 全33件
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pt. 1WL 100/H 236/v.83/ 2007042212007000543,
pt. 2WL 100/H 236/v.84/ 2007042212007000570 -
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
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pt. 1 ISBN 9780444519009
内容説明
This volume provides a complete guide to advancements made in the understanding of Parkinson's disease and related neurodegenerative disorders. From information on early research conducted in the 1960's, to modern clinical views of these diseases, this handbook will give clinicians and neuroscientists a state-of-the-art reference that presents critical appraisals on recent developments in the study of these disorders.
As the world population in developed countries ages, these observations are particularly relevant. Dramatic data on the genetic causes of dominant and recessive forms of hereditary Parkinson's disease are presented, as well as new knowledge on the differences in the intricate circuitry of basal ganglia in healthy individuals and those afflicted with Parkinson's.
Clinicians will find this to be a great platform on which to base ongoing investigative approaches and research.
目次
Section 1: Scientific foundation
Anatomy and physiology of the basal ganglia: relevance to parkinson's disease and related disorders. Functional neurochemistry of the basal ganglia. Dopamine receptor pharmacology.
Section 2: General aspects of Parkinson's disease
History of Parkinson's disease. Epidemiology of Parkinson's disease. Neurochemistry of the basal ganglia in Parkinson's disease. The neuropathology of parkinsonism. Imaging Parkinson's disease. Parkinson's disease: animal models.
Section 3: Clinical aspects
Scales to measure parkinsonism. Motor symptoms in Parkinson's disease. Autonomic dysfunction in Parkinson's disease. Sleep in Parkinson syndromes. Sensory symptoms in Parkinson's disease. Speech disorders in Parkinson's disease and the effects of pharmacological, surgical and speech treatment with emphasis on Lee Silverman voice treatment. Clinical features, pathophysiology and treatment of dementia associated with Parkinson's disease. Disorders of mood and affect in Parkinson's disease. Neurobehavioral disorders in Parkinson's disease. Early detection of Parkinson's disease.
Section 4: Etiology
Mitochondria in the etiology of Parkinson's disease. Iron as a trigger of neurodegeneration in Parkinson's disease. Oxidative stress and Parkinson's disease. Neurotrophic factors and Parkinson's disease. Neuroinflammation and Parkinson's disease. Excitotoxicity. Protein handling dysfunction in Parkinson's disease. Programmed cell death in Parkinson's disease.
- 巻冊次
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pt. 2 ISBN 9780444528933
内容説明
This volume provides comprehensive information on Parkinson's disease and related disorders, a group of diseases that are among the most common in the field of neurodegenerative study.
Through a high-level presentation of new research regarding these diseases, this handbook will give clinicians and neuroscientists alike a better understanding of the dramatic pharmacological advances made in the management of Parkinson's disease, and the profound observations that have altered the medical community's approach to other degenerative disorders of the nervous system.
Practitioners, researchers, and medical personnel will gain exciting insights into recent developments that form the basis for new therapeutic strategies and management protocols for the various neurological disorders that present with Parkinsonism.
目次
Section 5: Treatment of Parkinson's diseasePhysical therapy in Parkinson's disease. Neuroprotection in Parkinson's disease: clinical trials. Levodopa. Dopamine agonists. Monoamine oxidase A and B inhibitors in Parkinson's disease. Anticholinergic medications. Antiglutamatergic drugs in the treatment of Parkinson's disease. Investigational drugs. The importance of patients groups and collaborationSection 6: Complications of therapyMotor and non-motor fluctuations. Levodopa-induced dyskinesias in Parkinson's disease. Treatment induced mental changes in Parkinson's disease.Section 7 Surgical treatmentAblative surgery for the treatment of Parkinson's disease. Deep brain stimulation. Transplantation. Gene therapy approaches for the treatment of Parkinson's disease.Section 8: Other parkinsonian disease syndromesMultiple system atrophy. Progressive supranuclear palsy. Corticobasal degeneration. Infectious basis to the pathogenesis of Parkinson's disease. Toxic causes of Parkinson's disease. Drug induced parkinsonism. Vascular parkinsonism. Old age and Parkinson's disease. Other degenerative processes. Hydrocephalus and structural lesions. Calcification of the basal ganglia. Trauma and Parkinson's disease. Psychogenic parkinsonism. Parkinsonism and dystonia. Dementia with Lewy bodies. Myoclonus and parkinsonism.
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