Constitutive activity in receptors and other proteins
著者
書誌事項
Constitutive activity in receptors and other proteins
(Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 484-485)
Academic Press, 2010
- pt. A
- pt. B
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注記
Includes bibliographical references and indexes
内容説明・目次
- 巻冊次
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pt. B ISBN 9780123812964
内容説明
This volume of Methods in Enzymology covers the current methodology for the detection and assessment of constitutively active proteins. The chapters written by expert authors who are leaders in the field, provide hints and tricks not available in primary research publications.It is extensively referenced, with useful figures and tables throughout the volume.
目次
Identification and characterization of Steroidogenic Factor-1 inverse agonists.
Mabrouka Doghman, Franck Madoux, Peter Hodder, and Enzo Lalli
Assessment of inverse agonism for the angiotensin II type 1 receptor
Hiroshi Akazawa, Noritaka Yasuda, Shin-ichiro Miura, Issei Komuro
Measurement of inverse agonism in BARs
Carlos Alberto Taira
Inverse agonism of antidepressants: in vitro and in vivo studies
Joel Bockaert
Differential inverse agonism at the human muscarinic M3 receptor
Paola Casarosa
Ghrelin Receptor: High Constitutive Activity and Methods for Developing Inverse Agonists.
Constance Chollet
Constitutive activity and inverse agonism at the a1a and a1b adrenergic receptor subtypes.
Susanna. Cotecchia
Measurement of inverse agonism of the cannabinoid receptor
Tung Fong
Constitutively Active Thyrotropin (TSH) and Thyrotropin-Releasing Hormone (TRH) Receptors and Their Inverse Agonists
Marvin C. Gershengorn
Inverse retinoid agonists and neutral antagonists
Hinrich Gronemeyer
?-Aminobutyric Acid Type A (GABAA) Receptor Subtype Inverse Agonists as Therapeutic Agents in Cognition
Gabriella Guerrini and Ciciani Giovanna
Assays for inverse agonists in the visual system.
Masahiro Kono
Receptor-driven identification of novel human A3 adenosine receptor antagonists as potential therapeutic agents
Silvia Paoletta, Stephanie Federico, Giampiero Spalluto and Stefano Moro
Inverse agonists of steroidogenic factor SF-1
Fabrice Piu and Andria L. Del Tredici
Methods to Measure G Protein Coupled Receptor Activity for the Identification of Inverse Agonists
Gabriel Barreda-Gomez, M.Teresa Giralt and Rafael Rodriguez-Puertas
Section II-- Novel Strategies and Techniques for Constitutive Activity and Inverse Agonism
Use of Pharmacoperones to Reveal GPCR Structural Components Associated with Receptor Activation and Trafficking
Jo Ann Janovick and P. Michael Conn
Application of large-scale transiently transfected cells to functional assays of ion channels and other proteins.
Jun Chen, Sujatha Gopalakrishnan, Marc R Lake, and Bruce R Bianchi
Quantification of RNA Editing of the Serotonin 2C Receptor (5-HT2CR) Ex Vivo
Maria Fe Lanfranco, Noelle C. Anastasio, Patricia K. Seitz, and Kathryn A. Cunningham
Strategies for isolating constitutively-active and dominant-negative pheromone receptor mutants in yeast.
Mercedes Dosil and James B. Konopka
Development of a GPR23 Cell-based ss-Lactamase Reporter Assay
Paul H. Lee and Bonnie J. Hanson
Computational Modeling of Constitutively Active Mutants of GPCRs: C5a Receptor.
Gregory V. Nikiforovich and Thomas J. Baranski
TSH receptor monoclonal antibodies with agonist, antagonist and inverse agonist activities
Jane Sanders, Ricardo Nunez Miguel, Jadwiga Furmaniak, Bernard Rees Smith
Current standards, variations and pitfalls for the determination of constitutive TSHR activity in vitro
Sandra Mueller, Holger Jaeschke, Ralf Paschke
Towards the Rational Design of Constitutively Active KCa3.1 Mutant Channels
Line Garneau, Helene Klein, Lucie Parent, Remy Sauve
Fusion proteins as model systems for the analysis of constitutive GPCR activity
Erich H. Schneider, Roland Seifert
Screening for Novel Constitutively Active CXCR2 Mutants and Their Cellular Effects
Giljun Park, Tom Masi, Chang K. Choi, Heejung Kim, Jeffrey M. Becker, and Tim E. Sparer
A method for parallel solid-phase synthesis of iodinated analogues of the cannabinoid receptor type I (CB1) inverse agonist rimonabant
Alan C. Spivey and Chih-Chung Tseng
Coexpression systems as models for the analysis of constitutive GPCR activity
Roland Seifert and Erich H. Schneider
Modelling and simulation of inverse agonism dynamics
Lloyd J. Bridge
Design and Use of Constitutively Active STAT5 Constructs
Michael A. Farrar
In vitro and in vivo assays of protein kinase CK2 activity
Renaud Prudent, Celine F. Sautel, Virginie Moucadel, Beatrice Laudet, Odilhe Filhol, and Claude Cochet
- 巻冊次
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pt. A ISBN 9780123812988
内容説明
This volume of Methods in Enzymology covers the current methodology for the detection and assessment of constitutively active proteins. The chapters written by expert authors who are leaders in the field, provide hints and tricks not available in primary research publications.It is extensively referenced, with useful figures and tables throughout the volume.
目次
Section I-- Identification and Measurement of Constitutive Activity
Constitutive activity at the cannabinoid CB1 receptor and behavioral responses
Katherine E. Hanlon and Todd W. Vanderah
Detecting constitutive activity and protean agonism at the cannabinoid-2 receptor.
Massimiliano Beltramo, Rossella Brusa, Isabella Mancini, Paola Scandroglio, Massimiliano. Beltramo
Modulation of constitutive activity of the ghrelin receptor by use of pharmacological tools as well as mutagenesis
Birgitte Holst and Jacek Mokrosinski
Assessment of constitutive activity and internalization of GPR54 (Kiss1-r).
Macarena Pampillo and Andy Videsh Babwah
Assessment of Constitutive Activity in EP Prostanoid Receptors
Hiromichi Fujino, Toshihiko Murayama, and John W. Regan
a1D-Adrenergic receptors: constitutive activity and reduced expression at the plasma membrane
J Adolfo Garcia-Sainz, M. Teresa Romero-Avila and Luz del Carmen Medina
Constitutive activity of the histamine H1 receptor
Saskia Nijmeijer, Rob Leurs and Henry F Vischer
Constitutive activity of somatostatin receptor subtypes
Anat Ben-Shlomo, Kolja Wawrowsky and Shlomo Melmed
Assessment of homologous internalization of constitutively active N111G mutant of AT1 receptor
Mohiuddin Ahmed Bhuiyan and Takafumi Nagatomo
Methods to detect cell surface expression and constitutive activity of GPR6
Balakrishna M. Prasad, Bettye Hollins and Nevin A. Lambert
ss3-adrenoceptor agonists and (antagonists as) inverse agonists: history, perspective, constitutive activity and stereospecific binding.
Maria Grazia Perrone and Antonio Scilimati
Constitutive Activity of the Lutropin Receptor and its Allosteric Modulation by Receptor Heterodimerization
Deborah L. Segaloff
Assessing Constitutive Activity of Extracellular Calcium-Sensing Receptors in Vitro and in Bone
Wenhan Chang, Melita Dvorak, and Dolores Shoback
Constitutive Activity of Neural Melanocortin Receptors.
Ya-Xiong Tao, Hui Huang, Zhi-Qiang Wang, Fan Yang, Jessica N. Williams, and Gregory V. Nikiforovich
Measurement of Constitutive Activity of BMP Type I receptors
Peter ten Dijke
Probing the CA among dopamine D1 and D5 receptors and their mutants
Bianca Plouffe, Jean-Philippe D'Aoust, Vincent Laquerre, Binhui Liang and Mario Tiberi
Identification of Gain-of-Function Variants of the Human Prolactin Receptor
Vincent Goffin, Roman L. Bogorad, and Philippe Touraine
Investigations of Activated ACVR1/ALK2, a Bone Morphogenetic Protein (BMP) Type I Receptor that Causes Fibrodysplasia Ossificans Progressiva
Frederick. Kaplan, Petra Seemann, Julia Haupt, Meiqi Xu, Vitali Lounev, Mary Mullins, Eileen M. Shore
Identification and evaluation of constitutively active thyroid stimulating hormone receptor mutations
Joaquin Lado-Abeal, Leah R. Quisenberry, and Isabel Castro-Piedras
Assessment of constitutive activity of a G protein-coupled receptor, Cpr2, in Cryptococcus neoformans by heterologous and homologous methods
Chaoyang Xue, Yina Wang, and Yen-Ping Hsueh
In vitro and in vivo assessment of mu opioid receptor constitutive activity.
Edward J. Bilsky, Denise Giuvelis, Melissa D. Osborn, Christina M. Dersch, Heng Xu and Richard B. Rothman
Constitutively active -opioid methods
Mark. Connor and John Traynor
Protein Kinase Ck2 is a Constitutively-Active Enzyme That Promotes Cell Survival: Strategies To Identify Ck2 Substrates and Manipulate Its Activity In Mammalian Cells
Jacob P. Turowec, James S. Duncan, Ashley C. French, Laszlo Gyenis, Nicole A. St. Denis, Greg J. Vilk, and David W. Litchfield
Assessment of Ck2 Constitutive Activity In Cancer Cells
Maria Ruzzene, Giovanni Di Maira, Kendra Tosoni, and Lorenzo A. Pinna
Structural basis of the constitutive activity of protein kinase CK2
Birgitte B. Olsen, Barbara Guerra, Karsten Niefind and Olar-Georg Issinger font error
Measuring the Constitutive Activation of c-Jun N-terminal Kinase Isoforms
Ryan T. Nitta, Shawn S. Badal, and Albert J. Wong
Measurement of constitutive MAPK and PI3K/AKT signaling activity in human cancer cell lines.
Keiran S.M. Smalley
Constitutive activity of GPR40/FFA1: Intrinsic or assay dependent?
Leigh A Stoddart and Graeme Milligan
Constitutive activity of TRP channels: methods for measuring the activity and its outcome
Baruch Minke
Measurement of Orexin (Hypocretin) and Substance P Effects On Constitutively Active Inward Rectifier K+ Channels in Brain Neurons
Yasuko Nakajima and Shigehiro Nakajima
Characterization of G protein receptor kinase 4 and measuring its constitutive activity in vivo
Bradley T. Andresen
Voltage-clamp based methods for the detection of constitutively active acetylcholine-gated IK,ACh channels in the diseased heart
Niels Voigt, Samy Makary, Stanley Nattel, Dobromir Dobrev
Assaying Wave and WASH complex constitutive activities towards the Arp2/3 complex.
Emmanuel DERIVERY and Alexis GAUTREAU
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