Recent advances in electron cryomicroscopy

Author(s)

• Ludtke, Steven J
• Prasad, B. V. Venkataram

Bibliographic Information

Recent advances in electron cryomicroscopy

edited by Steven J. Ludtke and B.V. Venkataram Prasad

（Advances in protein chemistry and structural biology, v. 81-82）

Elsevier Academic Press, 2010-2011

• pt. A
• pt. B

Note

Includes bibliographical references and indexes

Description and Table of Contents

Volume

pt. A ISBN 9780123813572

Description

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Table of Contents

From envelopes to atoms: the remarkable progress of biological electron microscopy R. Anthony Crowther Single-particle applications at intermediate resolution Bettina Boettcher and Katharina Hipp Visualizing molecular machines in action: single particle analysis with structural variability Sjors H.W. Scheres Cellular Tomography Andreas Hoenger and Cedric Bouchet-Marquis

Volume

pt. B ISBN 9780123865076

Description

Electron cryomicroscopy is a form of transmission electron microscopy (EM) in which the sample is studied at cryogenic temperatures (generally liquid nitrogen temperatures). Cryo-EM is developing popularity in structural biology. This volume from the Advances in Protein Chemistry and Structural Biology series is Part B and covers essential topics.

Table of Contents

Single particle analysis at near atomic resolution Hong Zhou Single particle Tomography Michael Schmid Cellular tomography Andreas Hoenger Correlative light-electron microscopy Dorit Hanein Future prospects Michael Rossmann

by "Nielsen BookData"

Details

• NCID: BB04448132
• ISBN:
  • 9780123813572
  • 9780123865076
• Country Code: ne
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Amsterdam ; Tokyo
• Pages/Volumes: 2 v.
• Size: 24 cm
• Parent Bibliography ID:
  • BA88605553