Recent advances in electron cryomicroscopy
著者
書誌事項
Recent advances in electron cryomicroscopy
（Advances in protein chemistry and structural biology, v. 81-82）
Elsevier Academic Press, 2010-2011
- pt. A
- pt. B
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注記
Includes bibliographical references and indexes
内容説明・目次
- 巻冊次
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pt. A ISBN 9780123813572
内容説明
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.
While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
目次
From envelopes to atoms: the remarkable progress of biological electron microscopy
R. Anthony Crowther
Single-particle applications at intermediate resolution
Bettina Boettcher and Katharina Hipp
Visualizing molecular machines in action: single particle analysis with structural variability
Sjors H.W. Scheres
Cellular Tomography
Andreas Hoenger and Cedric Bouchet-Marquis
- 巻冊次
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pt. B ISBN 9780123865076
内容説明
Electron cryomicroscopy is a form of transmission electron microscopy (EM) in which the sample is studied at cryogenic temperatures (generally liquid nitrogen temperatures). Cryo-EM is developing popularity in structural biology. This volume from the Advances in Protein Chemistry and Structural Biology series is Part B and covers essential topics.
目次
Single particle analysis at near atomic resolution Hong Zhou
Single particle Tomography Michael Schmid
Cellular tomography Andreas Hoenger
Correlative light-electron microscopy Dorit Hanein
Future prospects Michael Rossmann
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